{
  "abstract": "Background: Multiple sclerosis (MS) is a chronic, inflammatory neurological condition characterized by debilitating symptoms, including fatigue, which significantly impacts patients’ quality of life. Probiotics are emerging as a potential intervention to alleviate MS-related fatigue through immunomodulatory and gut–brain axis effects. Objective: This study aimed to evaluate the efficacy of Familact, Multistrains probiotics, and a prebiotic, in reducing fatigue among MS patients compared to a placebo. Methods: A double-blind, randomized controlled trial was conducted with 54 MS patients allocated to receive either Familact or a placebo for 30 days. Fatigue levels were assessed using the Fatigue Severity Scale at baseline and after the intervention. Statistical analyses included appropriate comparative tests. Results: Patients receiving Familact showed significant improvements in fatigue levels compared to the placebo group, with no reported adverse reactions. Conclusions: Familact suggests the potential to reduce MS-related fatigue. Further large-scale, long-term studies are warranted to confirm these findings and explore underlying mechanisms.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Ali Jadidi"
    },
    {
      "name": "Bahareh Ranjbari"
    },
    {
      "name": "Alireza Rezaei Ashtiani"
    },
    {
      "name": "Mehdi Safarabadi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/drjm7a3ewxfh3.bib",
  "cited_by": 0,
  "doi": "10.4103/ijpvm.ijpvm_130_25",
  "fulltext_url": "https://www.ovid.com/jnls/ijom/fulltext/10.4103/ijpvm.ijpvm_130_25~the-role-of-synbiotics-in-alleviating-fatigue-among-multiple",
  "id": "drjm7a3ewxfh3",
  "issns": [
    "2008-7802",
    "2008-8213"
  ],
  "landing_url": "https://doi.org/10.4103/ijpvm.ijpvm_130_25",
  "language": "en",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2734|Multiple Sclerosis Research Studies"
    ]
  ],
  "openalex": "W7214747621",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Wolters Kluwer Medknow Publications",
  "ris": "https://research.draconitic.com/paper/drjm7a3ewxfh3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:54Z",
      "native_id": "5cf60d56a6934e99a9e2e1f052b9e6eb",
      "source": "doaj",
      "url": "https://doi.org/10.4103/ijpvm.ijpvm_130_25"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Multiple Sclerosis Research Studies",
      "subfield": "general"
    }
  ],
  "title": "The Role of Synbiotics in Alleviating Fatigue Among Multiple Sclerosis Patients: A Randomized Controlled Trial",
  "title_text": "The Role of Synbiotics in Alleviating Fatigue Among Multiple Sclerosis Patients: A Randomized Controlled Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:54Z",
  "url": "https://research.draconitic.com/paper/drjm7a3ewxfh3",
  "venue": "International Journal of Preventive Medicine",
  "versions": []
}