{
  "abstract": "Purpose: This study examined how attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) traits relate to depressive symptoms from late pregnancy through early postpartum in Japanese women, alongside perinatal factors.\n\nMethods: In a multicenter prospective study, 1,104 women completed questionnaires at late pregnancy (T1), 2 weeks postpartum (T2), and 1 month postpartum (T3). Depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS), ADHD traits with the Adult ADHD Self-Report Scale (ASRS), and ASD traits with the Autism Spectrum Quotient (AQ). Chi-square tests evaluated timepoint-specific associations, multivariable logistic regression identified independent predictors of EPDS positivity at T2, and a linear mixed-effects model assessed longitudinal changes.\n\nResults: EPDS scores and EPDS positivity were highest at T1 and declined postpartum (16.7%, 8.6%, 4.0%). Scores were correlated across timepoints. In univariate analyses, antenatal EPDS positivity showed associations with ASD traits (AQ+: OR = 6.08, 95% CI 2.17–16.99) and ADHD traits (ASRS+: OR = 4.86, 95% CI 3.06–7.72). In multivariable analysis, independent predictors of EPDS positivity at T2 included ADHD traits (OR = 1.37, 95% CI 1.13–1.66), primiparity, psychiatric treatment history, and antenatal EPDS scores. ASD traits were not associated with T2 EPDS positivity after adjustment for antenatal EPDS scores. In the mixed-effects model, both ADHD and ASD traits were associated with higher EPDS scores during pregnancy, with attenuated effects postpartum.\n\nConclusion: Neurodevelopmental traits are associated with perinatal mental health, and trait- and timing-informed support may enhance maternal psychological stability and caregiving outcomes.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00737-026-01781-4.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatrics, Minami-Nagano Medical Center, Shinonoi General Hospital, Nagano, Japan",
    "Graduate School of Medicine, Science and Technology, Shinshu University, Matsumoto, Japan",
    "Mental Health Clinic for Children, Shinshu University Hospital, Matsumoto, Japan",
    "Department of Child and Adolescent Developmental Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan",
    "Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan",
    "Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan",
    "Present Address: Department of Obstetrics and Gynecology, Nagano Red Cross Hospital, Nagano, Japan",
    "Department of Obstetrics and Gynecology, Minami-Nagano Medical Center, Shinonoi General Hospital, Nagano, Japan",
    "Itakura Ladies Clinic, Nagano, Japan",
    "Maruyama Obstetrics and Gynecology Hospital, Nagano, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Kyoko Hasegawa"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Daimei Sasayama",
      "orcid": "0000-0003-3450-7283"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Hideo Honda"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Norihiko Kikuchi"
    },
    {
      "affs": [
        7
      ],
      "name": "Takaaki Hondo"
    },
    {
      "affs": [
        8
      ],
      "name": "Kenji Itakura"
    },
    {
      "affs": [
        9
      ],
      "name": "Tomoko Watanabe"
    },
    {
      "affs": [
        4
      ],
      "name": "Shinsuke Washizuka"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/drztvz7wvw40w.bib",
  "cited_by": 0,
  "doi": "10.1007/s00737-026-01781-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736413/",
  "id": "drztvz7wvw40w",
  "issns": [
    "1434-1816",
    "1435-1102"
  ],
  "landing_url": "https://doi.org/10.1007/s00737-026-01781-4",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2739|Maternal Mental Health During Pregnancy and Postpartum"
    ]
  ],
  "openalex": "W7225231837",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00737-026-01781-4.pdf",
  "pmcid": "PMC13736413",
  "pmid": "42980824",
  "published": "2026-11-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/drztvz7wvw40w.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:52Z",
      "native_id": "PMC13736413",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00737-026-01781-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Maternal Mental Health During Pregnancy and Postpartum",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Associations between neurodevelopmental traits and perinatal depression: a prospective study in Japanese women",
  "title_text": "Associations between neurodevelopmental traits and perinatal depression: a prospective study in Japanese women",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:52Z",
  "url": "https://research.draconitic.com/paper/drztvz7wvw40w",
  "venue": "Archives of Women's Mental Health",
  "versions": []
}