{
  "abstract": "In CNS endothelial cells (ECs), VEGF signaling promotes vascular permeability, and Wnt/beta-catenin signaling reduces vascular permeability by controlling the gene expression program for the blood-brain barrier. Here we show, using genetic mosaics, that, in mouse brain ECs in vivo, an increase in Wnt/beta-catenin signaling produces an increase in VEGFR1 levels and a decrease in VEGFR2 levels, and a decrease in Wnt/beta-catenin signaling produces a decrease in VEGFR1 levels and an increase in VEGFR2 levels. As VEGFR1 functions as a decoy receptor to reduce VEGF signaling through VEGFR2, these data imply that Wnt/beta-catenin signaling acts at the receptor level to reduce VEGF signaling. In HEK/293T cells, VEGF signaling is suppressed by Wnt/beta-catenin signaling in a dose-dependent manner, with nearly complete suppression observed at levels of Wnt/beta-catenin signaling that produce little or no change in VEGF receptor levels. These data reveal two mechanisms by which VEGF signaling is regulated by Wnt/beta-catenin signaling.",
  "abstract_shown": true,
  "affiliations": [
    "Howard Hughes Medical Institute, Johns Hopkins University School of Medicine"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "J. Nathans"
    },
    {
      "name": "Y. Wang"
    },
    {
      "name": "N. Zhu"
    },
    {
      "name": "A. Rattner"
    },
    {
      "name": "P. M. Smallwood"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ds7j8rsy2gaxj.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.03.745507",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.03.745507v1.full",
  "id": "ds7j8rsy2gaxj",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.03.745507v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "developmental biology"
    ],
    [
      "openalex",
      "2808|Barrier Structure and Function Studies"
    ]
  ],
  "openalex": "W7211935815",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.03.745507v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ds7j8rsy2gaxj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:07Z",
      "native_id": "10.64898/2026.09.03.745507",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.03.745507v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:developmental biology",
      "subfield": "developmental-biology"
    }
  ],
  "title": "Wnt/beta-catenin signaling regulates Vascular Endothelial Growth Factor (VEGF) receptors in central nervous system endothelial cells",
  "title_text": "Wnt/beta-catenin signaling regulates Vascular Endothelial Growth Factor (VEGF) receptors in central nervous system endothelial cells",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:07Z",
  "url": "https://research.draconitic.com/paper/ds7j8rsy2gaxj",
  "venue": "bioRxiv",
  "versions": []
}