{
  "abstract": "Purpose: Pathological complete response (pCR) of neoadjuvant chemotherapy (NACT) is the most important predictor of successful treatment in locally advanced breast cancer and is associated with survival outcomes. The aim of our study is to investigate a validated nomogram that predicted MammaPrint® to assess the response rate in luminal type breast cancer. Methods: This study retrospectively included patients from Asan Medical Center, Seoul, South Korea who were diagnosed with luminal type breast cancer and received NACT and underwent breast cancer surgery from August 2008 to December 2021. We used a nomogram previously published by colleagues at our center, using a cutoff score of 183. The primary outcome of this study was to investigate the use of nomogram adopted from a 70-gene MammaPrint for prediction of pCR following NACT. Results: Data from 1,574 patients were collected. The nomogram using MammaPrint predicted pCR (odds ratio 2.092, 95% confidence interval 1.507–2.905; p < 0.001). Based on multivariate logistic regression analysis, estrogen receptor status, progesterone receptor status, clinical tumor stage, clinical node stage, and Ki67 index were independent predictive factors of pCR in the primary cohort. The area under the curve of the validated nomogram was 0.64 (95% confidence interval, 0.60–0.67), indicating the nomogram predicted pCR in the neoadjuvant setting. Conclusion: This study provides evidence that the adopted nomogram using the MammaPrint risk assessment based on clinicopathological pre-NACT factors can be utilized in luminal type breast cancer to aid in treatment decisions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Surgery, Al Adan Hospital, Hadiya, Ministry of Health, Kuwait",
    "Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sarah Al safi"
    },
    {
      "affs": [
        1
      ],
      "name": "Tae Kyung Yoo"
    },
    {
      "name": "Jisun Kim"
    },
    {
      "name": "Il Yong Chung"
    },
    {
      "name": "Beom Seok Ko"
    },
    {
      "name": "Hee Jeong Kim"
    },
    {
      "name": "Jong Won Lee"
    },
    {
      "name": "Byung Ho Son"
    },
    {
      "name": "Sae Byul Lee"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dsrn0xqarsayp.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0356871",
  "fulltext_url": null,
  "id": "dsrn0xqarsayp",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0356871",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|Breast Cancer Treatment Studies"
    ],
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      "plos",
      "/Biology and life sciences/Anatomy/Histology"
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      "/Medicine and health sciences/Epidemiology/Medical risk factors/Cancer risk factors"
    ],
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      "plos",
      "/Medicine and health sciences/Oncology/Cancer detection and diagnosis"
    ],
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      "plos",
      "/Medicine and health sciences/Oncology/Cancer risk factors"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancer treatment"
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    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancer treatment/Cancer chemotherapy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancer treatment/Surgical oncology"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Breast tumors/Breast cancer"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Clinical oncology/Cancer chemotherapy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Clinical oncology/Surgical oncology"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pharmaceutics/Drug therapy/Chemotherapy/Cancer chemotherapy"
    ],
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      "plos",
      "/Medicine and health sciences/Surgical and invasive medical procedures"
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  "openalex": "W7213915479",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0356871&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/dsrn0xqarsayp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "10.1371/journal.pone.0356871",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0356871"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:oncology",
      "subfield": "oncology"
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  "title": "Development and validation of a nomogram predicting pathologic complete response to neoadjuvant chemotherapy in luminal type breast cancer patients using MammaPrint® and clinicopathological factor",
  "title_text": "Development and validation of a nomogram predicting pathologic complete response to neoadjuvant chemotherapy in luminal type breast cancer patients using MammaPrint® and clinicopathological factor",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:43Z",
  "url": "https://research.draconitic.com/paper/dsrn0xqarsayp",
  "venue": "PLOS One",
  "versions": []
}