{
  "abstract": "The landmark ongoing HEALthy Brain and Child Development (HBCD) study will longitudinally chart brain development in a large sample (projected n = 7200) of infants through age 10 years with multimodal neuroimaging that includes an advanced diffusion MRI (dMRI) acquisition. Here, we detail advances in dMRI image processing developed for HBCD, incorporated into the widely used QSIPrep pipeline. Major changes to preprocessing include improvements in infant brain extraction, distortion correction, and normalization to infant-specific templates. Additionally, we describe a new software package – QSIRecon – that yields rich derived data including diverse maps of tissue microstructure as well as person-specific white matter bundles. Using dMRI data from a subset of the HBCD 1.0 release where age information was available (n = 529 sessions across two time points), we observe critical improvements in data quality with preprocessing and see expected developmental patterns. Moving forward, the publicly-available data from HBCD will rapidly grow to become the largest study of brain development in infancy and early childhood using dMRI. QSIPrep and QSIRecon are openly available and can be applied to other infant and pediatric dMRI datasets.",
  "abstract_shown": true,
  "affiliations": [
    "Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States",
    "Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States",
    "Lifespan Brain Institute (LiBI), The Children’s Hospital of Philadelphia and Perelman School of Medicine, Philadelphia, PA, United States",
    "National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, United States",
    "National Institutes of Health, Bethesda, MD, United States",
    "Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States",
    "PICSL Lab, Department of Radiology, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, United States",
    "Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States",
    "Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, Boston, MA, United States",
    "Department of Pediatrics, Harvard Medical School, Boston, MA, United States",
    "Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, United States",
    "Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, United States",
    "Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, United States",
    "Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States",
    "Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States",
    "F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States",
    "Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States",
    "Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, CA, United States",
    "Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, United States",
    "Institute of Child Development, College of Education and Human Development, University of Minnesota, Minneapolis, MN, United States",
    "Department of Neurology, Washington University in St. Louis, St. Louis, MO, United States",
    "Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, United States",
    "Department of Radiology, Washington University in St. Louis, St. Louis, MO, United States",
    "Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, United States",
    "Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, United States",
    "Vanderbilt University, Nashville, TN, United States",
    "The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, United States",
    "Department of Pediatrics, University of Southern California, Los Angeles, CA, United States",
    "Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States",
    "University of Wisconsin – Madison, Madison, WI, United States"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
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        0,
        1,
        2
      ],
      "name": "Matthew Cieslak"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "M. Okan Irfanoglu"
    },
    {
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        0,
        1,
        2
      ],
      "name": "Steven L. Meisler"
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      "name": "Taylor Salo"
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    {
      "affs": [
        5
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      "name": "Adam C. Raikes"
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    {
      "affs": [
        6
      ],
      "name": "Philip A. Cook"
    },
    {
      "affs": [
        7,
        8,
        9
      ],
      "name": "Ai Wern Chung"
    },
    {
      "affs": [
        10,
        11,
        12
      ],
      "name": "Erik G. Lee"
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    {
      "affs": [
        13,
        14
      ],
      "name": "Ruolin Li"
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    {
      "affs": [
        15,
        16
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      "name": "Xu Li"
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    {
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        17
      ],
      "name": "Diliana Pecheva"
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        10,
        18,
        19
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      "name": "Damien A. Fair"
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    {
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        22,
        23,
        24
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      "name": "Christopher D. Smyser"
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    {
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        23
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      "name": "Michael P. Harms"
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    {
      "affs": [
        25
      ],
      "name": "Bennett A. Landman"
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    {
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        26,
        27
      ],
      "name": "Jessica L. Wisnowski"
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    {
      "affs": [
        13,
        28
      ],
      "name": "Hao Huang"
    },
    {
      "affs": [
        29
      ],
      "name": "Andrew L. Alexander"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Theodore D. Satterthwaite"
    }
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  "bibtex": "https://research.draconitic.com/paper/dt875h4zdv657.bib",
  "cited_by": 8,
  "doi": "10.1016/j.dcn.2026.101838",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734816/",
  "id": "dt875h4zdv657",
  "issns": [
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  "landing_url": "https://doi.org/10.1016/j.dcn.2026.101838",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
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      "openalex",
      "2741|Advanced Neuroimaging Techniques and Applications"
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  "pdf_url": null,
  "pmcid": "PMC13734816",
  "pmid": "42933192",
  "published": "2026-10-15",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/dt875h4zdv657.ris",
  "sources": [
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  "subjects": [
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      "subfield": "imaging"
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  "title": "Diffusion MRI processing in the HEALthy Brain and Child Development study: Innovations and applications",
  "title_text": "Diffusion MRI processing in the HEALthy Brain and Child Development study: Innovations and applications",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:38Z",
  "url": "https://research.draconitic.com/paper/dt875h4zdv657",
  "venue": "Developmental Cognitive Neuroscience",
  "versions": []
}