{
  "abstract": "This study aimed to determine the chemical composition of Thymus hirtus essential oil and to assess its acute toxicity and anti-inflammatory potential. This essential oil extracted by hydrodistillation from the leaves has a yield of 2.08 ± 0.5 %. The identification of its chemical composition was conducted using both GC-FID and GC-MS. Fifty-four constituents were detected, representing 98.53 % of the essential oil's composition. The major constituents were : thymol (48.5 %) and carvacrol (17.75 %). The oral acute toxicity of this essential oil was evaluated in mice by administering single doses ranging from 50 to 2000 mg/kg. The lethal dose (LD50) obtained was equal to 875 mg/kg. The anti-inflammatory activity was assessed using carrageenan-induced paw edema test in mice. A notable reduction of paw edema was obtained at dose of 50 mg/kg (50.9 %) and 100 mg/kg (65.6 %). The reported anti-inflammatory activity represents a significant initial outcome, underscoring the relevance of this work and paving the way for future investigations to validate and extend these findings.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "name": "Meriem TOUAIBIA"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dtrtzvwers3eq.bib",
  "cited_by": 0,
  "doi": "10.5650/jos.ess25191",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess25191/_article",
  "id": "dtrtzvwers3eq",
  "issns": [
    "1347-3352",
    "1345-8957"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess25191/_article",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "chemistry/general"
    ],
    [
      "openalex",
      "1106|Essential Oils and Antimicrobial Activity"
    ]
  ],
  "openalex": "W7171972238",
  "pdf_url": "https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess25191/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dtrtzvwers3eq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.5650/jos.ess25191",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess25191/_article"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "jstage-journal:chemistry/general",
      "subfield": "general"
    }
  ],
  "title": "Chemical composition, oral acute toxicity and anti-inflammatory activity of Thymus hirtus Willd. essential oil.",
  "title_text": "Chemical composition, oral acute toxicity and anti-inflammatory activity of Thymus hirtus Willd. essential oil.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:38Z",
  "url": "https://research.draconitic.com/paper/dtrtzvwers3eq",
  "venue": "Journal of Oleo Science",
  "versions": []
}