{
  "abstract": "The creation of single-site catalysts, for which all active sites have the same structure, is a key goal in contemporary heterogeneous catalysis. Many MOF linkers present well-defined binding sites for transition metals and may thus provide access to single-site catalysts. Depending on how the metal is introduced into the linker-based binding site, however, additional undesired species such as pore-confined nanoparticles or node-bound metal centers may be formed that can be difficult to locate. Here, we introduce catalytic interrogation as a diagnostic workflow for identifying the types of active sites that contribute to the catalytic activity observed for MOF catalysts. Using a suite of MOFs with porphyrin linkers as a case study, we combine catalytic interrogation with extensive electron microscopy to shed light on the rhodium-based active sites present in the MOF. We show that for strongly coordinating binding sites that furnish leaching-proof MOF-based catalysts, post-synthetic metalation carries a significant risk of undesired nanoparticle incorporation. MOF assembly from metalated linkers, on the other hand, generates MOFs that behave as single-site catalysts.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Hao Deng"
    },
    {
      "name": "Zihang Qiu"
    },
    {
      "name": "Alin B. Schöne"
    },
    {
      "name": "Walid Hetaba"
    },
    {
      "name": "Constanze Nicole Neumann",
      "orcid": "0000-0003-1004-1140"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dv76sngyytbmk.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010749/v1",
  "fulltext_url": null,
  "id": "dv76sngyytbmk",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010749/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1604|Metal-Organic Frameworks: Synthesis and Applications"
    ]
  ],
  "openalex": "W7223146351",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010749/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/dv76sngyytbmk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15010749",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010749/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1604|Metal-Organic Frameworks: Synthesis and Applications",
      "subfield": "inorganic"
    }
  ],
  "title": "Synthesis of Leaching-Proof Single-Site Catalysts Based on Metallolinker MOFs",
  "title_text": "Synthesis of Leaching-Proof Single-Site Catalysts Based on Metallolinker MOFs",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/dv76sngyytbmk",
  "venue": "ChemRxiv",
  "versions": []
}