{
  "abstract": "Host-virus interactions remain poorly understood in archaea, whose information processing systems harbor a mosaic of bacterial and eukaryotic features. Here, we used complementary multiomics to investigate interactions between Haloferax tailed virus 1 (HFTV1) and the halophilic archaeon Haloferax gibbonsii (Hg), capturing global translational and transcriptional dynamics across the infection cycle. This revealed co-regulatory expression patterns across HFTV1 and Hg genes. Post-transcriptional regulation was observed for several early HFTV1 genes and the late HFTV1 gene gp17, and the HFTV1 tRNA co-sedimented with Hg ribosome complexes. Infection reshaped the translational landscape of Hg, causing a slow decline in information processing activity, a complex transcriptional response, and amino acid starvation. An unannotated Tat-dependent fimbrial system of Hg was co-regulated with early HFTV1 genes and was correlated with increased biofilm formation, suggesting a potential antiviral defense system. These findings provide high-resolution insight into archaeal host-virus interactions at the evolutionary interface between bacteria and eukaryotes.",
  "abstract_shown": true,
  "affiliations": [
    "Johns Hopkins University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "M. F. Isada"
    },
    {
      "name": "P. Gregorova"
    },
    {
      "name": "P. Sadana"
    },
    {
      "name": "P. Sarin"
    },
    {
      "affs": [
        0
      ],
      "name": "J. DiRuggiero"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dve9cvc0b6vab.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.13.751334",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.13.751334v1.full",
  "id": "dve9cvc0b6vab",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.13.751334v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "microbiology"
    ],
    [
      "openalex",
      "1312|RNA and protein synthesis mechanisms"
    ]
  ],
  "openalex": "W7213367078",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.13.751334v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dve9cvc0b6vab.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:33Z",
      "native_id": "10.64898/2026.09.13.751334",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.13.751334v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Ribosome profiling reveals translational dynamics between an archaeal virus and its host",
  "title_text": "Ribosome profiling reveals translational dynamics between an archaeal virus and its host",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:33Z",
  "url": "https://research.draconitic.com/paper/dve9cvc0b6vab",
  "venue": "bioRxiv",
  "versions": []
}