{
  "abstract": "Introduction: Clinical activity score (CAS) is widely used to assess thyroid eye disease (TED) activity, but its predictive value in East Asian patients remains unclear. This study evaluated the correlations between CAS and both radiological and serological markers in treatment-naïve ethnic Han Chinese TED patients.\n\nMethods: A cross-sectional study of treatment-naïve ethnic Han Chinese TED patients was managed at The Chinese University of Hong Kong between January 2014 and May 2022. STIR signal intensity was quantified using signal intensity ratio (SIR), while disease activity was assessed clinically using CAS.\n\nResults: A total of 188 patients with a mean onset age of 50 ± 14 years who underwent baseline MRI were included. The mean presenting CAS was 1.4 ± 1.3. A weak positive correlation was observed between CAS and the SIR of the levator palpebral superioris/superior rectus complex (r = 0.196, p = 0.00709). Nominal positive correlations were observed between CAS and the SIRs of the inferior rectus (r = 0.185, p = 0.0112) and medial rectus (r = 0.167, p = 0.0224). In subgroup analysis of patients presenting with CAS ≥3, nominal positive correlations were observed between CAS and the SIRs of the lateral rectus (r = 0.374, p = 0.0416), medial rectus (r = 0.351, p = 0.0487), and inferior rectus (r = 0.335, p = 0.0348). No correlation was identified in patient with CAS <3. No significant correlation was found between CAS and serological markers.\n\nConclusions: The correlation between CAS and STIR signals was generally weak, and no significant correlation was identified between CAS and serological markers. These findings suggest that orbital MRI may provide complementary information beyond clinical assessment in evaluating disease activity in ethnic Chinese TED patients.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR",
    "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, Hong Kong SAR",
    "Department of Ophthalmology, Vicente Sotto Memorial Medical Center, Cebu City, Philippines",
    "Hong Kong Laser Eye Centre, Hong Kong, Hong Kong SAR",
    "Department of Imaging and Interventional Radiology, Prince of Wales Hospital, Hong Kong, Hong Kong SAR",
    "Hong Kong Eye Hospital, Hong Kong, Hong Kong SAR",
    "Division of Endocrinology and Metabolism, Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong SAR",
    "Department of Medicine, Queen Elizabeth Hospital, Hong Kong, Hong Kong SAR",
    "Eye Center, The Chinese University of Hong Kong Medical Center, Hong Kong, Hong Kong SAR"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
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        0,
        1
      ],
      "name": "Kenneth Ka Hei Lai"
    },
    {
      "affs": [
        0
      ],
      "name": "Fatema Mohamed Ali Abdulla Aljufairi"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Jake Uy Sebastian"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicole Tsz Yan Wong"
    },
    {
      "affs": [
        0
      ],
      "name": "Kevin Ka Fai Yuen"
    },
    {
      "affs": [
        0
      ],
      "name": "Carly S.K. Yeung"
    },
    {
      "affs": [
        3
      ],
      "name": "George Pak Man Cheng"
    },
    {
      "affs": [
        4
      ],
      "name": "Winnie Chiu Wing Chu"
    },
    {
      "affs": [
        1
      ],
      "name": "Wilson Wai Kuen Yip"
    },
    {
      "affs": [
        1
      ],
      "name": "Alvin Lerrmann Young"
    },
    {
      "affs": [
        5
      ],
      "name": "Hunter Kwok Lai Yuen"
    },
    {
      "affs": [
        6
      ],
      "name": "Alan Chun Hong Lee"
    },
    {
      "affs": [
        7
      ],
      "name": "Chiu Ming Ng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Clement Chee Yung Tham"
    },
    {
      "affs": [
        0
      ],
      "name": "Chi Pui Pang"
    },
    {
      "affs": [
        0,
        1,
        5,
        8
      ],
      "name": "Kelvin Kam Lung Chong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dvgj9dfqeprk4.bib",
  "cited_by": 0,
  "doi": "10.1159/000553278",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13716393/",
  "id": "dvgj9dfqeprk4",
  "issns": [
    "0030-3747",
    "1423-0259"
  ],
  "landing_url": "https://doi.org/10.1159/000553278",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Ocular Plastics"
    ],
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      "openalex",
      "2734|Ophthalmology and Eye Disorders"
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  "openalex": "W7166517600",
  "pdf_url": "https://karger.com/ore/article-pdf/doi/10.1159/000553278/4555107/000553278.pdf",
  "pmcid": "PMC13716393",
  "pmid": "42371852",
  "published": "2026-06-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dvgj9dfqeprk4.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:23:23Z",
      "native_id": "PMC13716393",
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      "url": "https://doi.org/10.1159/000553278"
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      "field": "medicine",
      "origin": "openalex:2734|Ophthalmology and Eye Disorders",
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  "title": "Correlations between Clinical Activity Score and Serological and Radiological Data in Treatment-Naïve Ethnic Han Chinese Thyroid Eye Disease",
  "title_text": "Correlations between Clinical Activity Score and Serological and Radiological Data in Treatment-Naïve Ethnic Han Chinese Thyroid Eye Disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:23Z",
  "url": "https://research.draconitic.com/paper/dvgj9dfqeprk4",
  "venue": "Ophthalmic Research",
  "versions": []
}