{
  "abstract": "Pre-existing Orthoflavivirus immunity can shape antibody recall upon infection with a heterologous virus. We monitored Zika virus (ZIKV) infection in individuals vaccinated against yellow fever virus (YFV), with or without prior dengue virus (DENV) exposure. We obtained longitudinal serology data (NS1- and whole-virus IgG responses) and neutralization titers on days 0 and 28 after ZIKV infection. YFV-neutralizing antibody levels remained stable over time, consistent with the long-lasting immunity induced by YFV vaccination. By contrast, ZIKV infection triggered an increase in anti-YFV NS1 IgG, suggesting a selective recall of YFV-specific memory B cells. A similar trend was observed for anti-DENV NS1 IgG exclusively in DENV-immune individuals. Thus, prior Orthoflavivirus exposure shapes the specificity and magnitude of NS1-directed humoral recall, with implications for serological interpretation.",
  "abstract_shown": true,
  "affiliations": [
    "Institut de Recherche Biomedicale des Armees"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "S. Marquine"
    },
    {
      "name": "N. Ayhan"
    },
    {
      "name": "K. M. Meneyrol"
    },
    {
      "name": "E. Le Dault"
    },
    {
      "name": "S. Attoumani"
    },
    {
      "name": "E. Nurtop"
    },
    {
      "name": "G. Grard"
    },
    {
      "name": "A. Trignol"
    },
    {
      "name": "b. coutard"
    },
    {
      "name": "M. Mura"
    },
    {
      "name": "s. briolant"
    },
    {
      "affs": [
        0
      ],
      "name": "C. Badaut"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dvksm0eegf3mp.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.10.26362723",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.10.26362723v1.full",
  "id": "dvksm0eegf3mp",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.10.26362723v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "infectious diseases"
    ],
    [
      "openalex",
      "2739|Mosquito-borne diseases and control"
    ]
  ],
  "openalex": "W7212381922",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.10.26362723v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dvksm0eegf3mp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:23Z",
      "native_id": "10.64898/2026.09.10.26362723",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.10.26362723v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:infectious diseases",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Kinetics and specificity of orthoflaviviruses NS1 IgG after Zika virus infection in Yellow fever and dengue immunized individuals: a memory recall hypothesis",
  "title_text": "Kinetics and specificity of orthoflaviviruses NS1 IgG after Zika virus infection in Yellow fever and dengue immunized individuals: a memory recall hypothesis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:18:23Z",
  "url": "https://research.draconitic.com/paper/dvksm0eegf3mp",
  "venue": "medRxiv",
  "versions": []
}