{
  "abstract": "Introduction\n\nThe electrical stimulation of peripheral nerves has shown the potential to restore impaired functions across a wide range of clinical scenarios. In most cases, though, the lack of selectivity of existing stimulation interfaces limits their applicability and can in some cases produce severe adverse effects. In addition, traditional stimulation requires physical connectors to a pulse generator that can add further biological and mechanical stress already linked to interfacing with physiological structures. This study focuses on the use of magnetoelectric nanoparticles (MENPs) embedded within conductive polymeric nanofibers as new wireless, highly selective, and minimally invasive interfaces for modulating peripheral nerves activity.Methods\n\nA step-by-step detailed characterization of the physical variables involved in this interaction, spanning from the nanometric single MENPs to micrometric multi-nanofibers structure with dispersed MENPs (poly-ME devices) and ending with the millimetric peripheral nerve, was proposed. MENPs concentration and distribution, device geometry, orientation, and size were systematically varied, and their effects on nerve fiber recruitment were quantified across myelinated and unmyelinated fiber types at different distances from the stimulating source.Results and discussion\n\nOur results evidenced how higher MENPs concentrations, higher stimulating source size and lower distance enhance the modulation capability of the poly-ME devices, with differences in stimulation capability between myelinated and unmyelinated nerve fibers. The solution of embedding MENPs in conductive polymer nanofibers enables higher MENPs loading than direct tissue injection, improves positional stability, and preserves biocompatibility, thereby offering a potential alternative for the engineering of MENPs as neuromodulation interfaces.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Milan, Italy.",
    "Institute of Electronics, Computer and Telecommunication Engineering (IEIIT), National Research Council (CNR), Milan, Italy.",
    "The BioRobotics institute, Health Science Interdisciplinary Research Center, and Department of Excellence Robotics and AI, Scuola Superiore Sant'anna, Pisa, Italy.",
    "Institute of Nanotechnology, National Research Council (CNR NANOTEC), Lecce, Italy.",
    "Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies, Arnesano (LE), Italy.",
    "Tecnomed Puglia - Technopole for Precision Medicine (Biotech Lecce Hub), Lecce, Italy.",
    "Modular Implantable Neurotechnologies (MINE) Laboratory, Università Vita Salute San Raffaele and Scuola Superiore Sant'Anna, Milan, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Valentina Galletta"
    },
    {
      "affs": [
        1
      ],
      "name": "Serena Fiocchi"
    },
    {
      "affs": [
        2
      ],
      "name": "Claudio Verardo"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Luigi Carbone"
    },
    {
      "affs": [
        3,
        5
      ],
      "name": "Loretta Laureana Del Mercato"
    },
    {
      "affs": [
        6
      ],
      "name": "Simone Romeni"
    },
    {
      "affs": [
        1
      ],
      "name": "Emma Chiaramello"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dvs15hrygx5br.bib",
  "cited_by": 0,
  "doi": "10.3389/fbioe.2026.1951247",
  "fulltext_url": "https://europepmc.org/articles/PMC13710225",
  "id": "dvs15hrygx5br",
  "issns": [
    "2296-4185"
  ],
  "landing_url": "https://europepmc.org/article/MED/42947980",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2804|Neuroscience and Neural Engineering"
    ]
  ],
  "openalex": "W7221661888",
  "pdf_url": "https://europepmc.org/articles/PMC13710225?pdf=render",
  "pmcid": "PMC13710225",
  "pmid": "42947980",
  "published": "2026-10-13",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/dvs15hrygx5br.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:34Z",
      "native_id": "MED:42947980",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42947980"
    },
    {
      "first_seen": "2026-10-31T12:21:14Z",
      "native_id": "PMC13710225",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fbioe.2026.1951247"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Neuroscience and Neural Engineering",
      "subfield": "neuroscience"
    }
  ],
  "title": "Multi-scale computational modeling of magnetoelectric nanoparticle-dispersed conductive nanofibers for peripheral nerve modulation.",
  "title_text": "Multi-scale computational modeling of magnetoelectric nanoparticle-dispersed conductive nanofibers for peripheral nerve modulation.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:14Z",
  "url": "https://research.draconitic.com/paper/dvs15hrygx5br",
  "venue": "Frontiers in bioengineering and biotechnology",
  "versions": []
}