{
  "abstract": "The evolution of the vertebrate limb-torso-limb body plan drove a diversification of motor behavior. How neural circuits are organized to generate distinct outputs across body regions, however, remains unknown. Here, we construct a cross-species, spatiotemporal atlas of spinal interneurons spanning the rostrocaudal and developmental axes of frogs and mice. We uncover a common framework of interneuron regionalization that mirrors each vertebrate's body plan and arises through Hox-dependent regulation of rostrocaudal neurogenesis. Combining electrophysiology with computational modeling, we show that changing regional circuit composition is sufficient to respecify motor output. Together, these findings establish a causal link between developmental patterning, circuit architecture, and motor function, identifying interneuron regionalization as a fundamental organizational principle linking body-plan evolution to motor diversity.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Stavros Papadopoulos"
    },
    {
      "name": "August Winther"
    },
    {
      "name": "Florina Alexandra Toma"
    },
    {
      "name": "Kareem Elassy"
    },
    {
      "name": "Clara Julseth"
    },
    {
      "name": "Remi Ronzano"
    },
    {
      "name": "Ying Zhang"
    },
    {
      "name": "Tim P Vogels"
    },
    {
      "name": "Didier Le Ray"
    },
    {
      "name": "Lora B Sweeney"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dw459r6gz77jj.bib",
  "cited_by": 1,
  "doi": "10.64898/2026.07.02.736051",
  "fulltext_url": null,
  "id": "dw459r6gz77jj",
  "issns": [],
  "landing_url": "https://hal.science/hal-05768706v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1312|Developmental Biology and Gene Regulation"
    ]
  ],
  "openalex": "W7167246510",
  "pdf_url": "https://hal.science/hal-05768706/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dw459r6gz77jj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:42Z",
      "native_id": "hal-05768706",
      "source": "hal",
      "url": "https://hal.science/hal-05768706v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Developmental Biology and Gene Regulation",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Spinal circuit regionalization diversifies motor output along the vertebrate body axis",
  "title_text": "Spinal circuit regionalization diversifies motor output along the vertebrate body axis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:42Z",
  "url": "https://research.draconitic.com/paper/dw459r6gz77jj",
  "venue": "HAL",
  "versions": []
}