{
  "abstract": "Objectives\n\nCarbapenem-resistant Enterobacterales (CRE) are a common source of healthcare-associated infections and nosocomial outbreaks. We examined a suspected nosocomial outbreak of carbapenem-resistant Klebsiella aerogenes in a surgical ward over a period of 11 months.Methods\n\nWe used whole-genome sequencing (WGS) to assess the genetic relatedness of eight detected isolates.Results\n\nMolecular epidemiological analyses confirmed the outbreak as a pseudo-outbreak. During the period of assessment, the hospital infection control team implemented multiple interventions to promote stringent hand hygiene compliance, appropriate use of personal protective equipment, and adherence to best practices for wound care and body fluid management. Despite these measures, intermittent CRE isolation continued. Notably, WGS analyses revealed that all assessed isolates were genetically unique, with no evidence to indicate clonal relatedness.Conclusions\n\nThe suspected nosocomial outbreak comprised sporadic, unrelated cases of CRE. Our findings in this study highlight the significance of molecular epidemiological tools in precisely evaluating suspected outbreaks of CRE and in directing the effective deployment of infection control resources.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.",
    "Infection Prevention and Control Unit, Department of Infection Prevention and Control, Juntendo University Hospital, Tokyo, Japan.",
    "Department of Clinical Laboratory Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.",
    "Department of Clinical Laboratory, Juntendo University Hospital, Tokyo, Japan.",
    "Department of Infection Control Science, Juntendo University Graduate School of Medicine, Tokyo, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Mahoko Ikeda"
    },
    {
      "affs": [
        1
      ],
      "name": "Sachiko Hirose"
    },
    {
      "affs": [
        2
      ],
      "name": "Satomi Takei"
    },
    {
      "affs": [
        3
      ],
      "name": "Gene Igawa"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Satoshi Hori"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yuki Uehara"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Akio Kanazawa"
    },
    {
      "affs": [
        0
      ],
      "name": "Mai Suzuki"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yoko Tabe"
    },
    {
      "affs": [
        0
      ],
      "name": "Toshio Naito",
      "orcid": "0000-0003-1646-9930"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dw8b4a5c1nxzk.bib",
  "cited_by": 0,
  "doi": "10.1016/j.infpip.2026.100596",
  "fulltext_url": "https://europepmc.org/articles/PMC13681980",
  "id": "dw8b4a5c1nxzk",
  "issns": [
    "2590-0889"
  ],
  "landing_url": "https://europepmc.org/article/MED/42904077",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|Infection Control in Healthcare"
    ]
  ],
  "openalex": "W7213886390",
  "pdf_url": "https://europepmc.org/articles/PMC13681980?pdf=render",
  "pmcid": "PMC13681980",
  "pmid": "42904077",
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dw8b4a5c1nxzk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42904077",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42904077"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Infection Control in Healthcare",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Molecular epidemiological analysis of a suspected nosocomial outbreak of carbapenem-resistant Klebsiella aerogenes.",
  "title_text": "Molecular epidemiological analysis of a suspected nosocomial outbreak of carbapenem-resistant Klebsiella aerogenes.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/dw8b4a5c1nxzk",
  "venue": "Infection prevention in practice",
  "versions": []
}