{
  "abstract": "Background: Endometriosis, a common gynecological disorder characterized by ectopic endometrial tissue, has complex epigenetic mechanisms. This study provides a comprehensive bibliometric analysis of research trends in endometriosis epigenetics.\n\nMethods: Articles on endometriosis epigenetics published from 2005 to 2026 were analyzed using the R package “bibliometrix,” VOSviewer, and CiteSpace to visualize research hotspots, key contributors, and emerging topics.\n\nResults: A total of 1175 articles were included, with the China leading (442 publications). Fudan University is the top institutions (76 articles, 6.4%), and Professor Taylor Hugh S. was the most prolific author (33 articles, 2.8%). Research hotspots included DNA methylation (notably HOXA10, SF-1, PR-B, ERβ, and GATA factors), histone modifications, and non-coding RNA regulation. Recent trends focus on novel epigenetic biomarkers and targeted therapies.\n\nConclusions: This analysis highlights DNA methylation and non-coding RNAs as central in endometriosis epigenetics. Continued research should prioritize discovering biomarkers and translations into clinical practice.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s13148-026-02220-y.",
  "abstract_shown": true,
  "affiliations": [
    "The First Clinical Medical College, Ningxia Medical University, Yinchuan 750004 Ningxia, China",
    "Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, 750004 Ningxia China",
    "Department of Gynecology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004 China",
    "Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004 China",
    "Present Address: Department of Gynecology, General Hospital of Ningxia Medical University, No.692 Shengli Street, Xingqing District, Ningxia Hui Autonomous Region, Yinchuan, Ningxia 750004 China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaohua Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yiyun Bai"
    },
    {
      "affs": [
        1
      ],
      "name": "Sang Luo"
    },
    {
      "affs": [
        1
      ],
      "name": "Yiran Jin"
    },
    {
      "affs": [
        0
      ],
      "name": "Junxian Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaxia An"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Dan Liu",
      "orcid": "0000-0002-5731-9122"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dwhv4va1p8hf7.bib",
  "cited_by": 0,
  "doi": "10.1186/s13148-026-02220-y",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729678/",
  "id": "dwhv4va1p8hf7",
  "issns": [
    "1868-7075",
    "1868-7083"
  ],
  "landing_url": "https://doi.org/10.1186/s13148-026-02220-y",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2743|Endometriosis Research and Treatment"
    ]
  ],
  "openalex": "W7172327951",
  "pdf_url": null,
  "pmcid": "PMC13729678",
  "pmid": "42978001",
  "published": "2026-08-03",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/dwhv4va1p8hf7.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:26Z",
      "native_id": "PMC13729678",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s13148-026-02220-y"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Endometriosis Research and Treatment",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Research progress and trends on epigenetics and endometriosis: a bibliometric analysis",
  "title_text": "Research progress and trends on epigenetics and endometriosis: a bibliometric analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:26Z",
  "url": "https://research.draconitic.com/paper/dwhv4va1p8hf7",
  "venue": "Clinical Epigenetics",
  "versions": []
}