{
  "abstract": "Purpose: To estimate the ciprofol pump-predicted effect-site target concentration associated with a 50% probability of suppressing the cardiovascular response to tracheal intubation (Ce50) during fixed sufentanil-esketamine induction in two age cohorts.\n\nPatients and Methods: In this single-center, prospective, age-stratified Dixon up-and-down study, 53 adults undergoing elective surgery received sufentanil 0.3 μg/kg, esketamine 0.3 mg/kg, and ciprofol effect-site target-controlled infusion (TCI). Independent cohorts aged 45–64 and 65–79 years started at a pump-predicted target concentration (Ce) of 1.10 μg/mL, adjusted in 0.05 μg/mL steps. Ce50 was estimated by reversal-pair midpoints and Probit analysis. The trial was registered on March 31, 2026 (ChiCTR2600121464).\n\nResults: Thirty-two middle-aged and 21 older adults were analyzed. Midpoint Ce50 was 0.975 μg/mL (approximate 95% confidence interval [CI], 0.910–1.040) and 1.096 μg/mL (1.072–1.121), respectively. Probit Ce50 was 0.991 μg/mL (95% CI, 0.773–1.103) and 1.112 μg/mL (1.078–1.152). At target Ce, mean arterial pressure fell by 19.2% ± 11.0% and 22.5% ± 12.5% from baseline. Hypotension occurred in 20/32 (62.5%) and 13/21 (61.9%) participants.\n\nConclusion: These exploratory Ce50 estimates are specific to the CONCERT-III pump model and the studied co-induction and rescue protocol in small, nonrandomized cohorts at a single center. Frequent hypotension and norepinephrine use accompanied induction. The estimates do not establish an independent age effect or individual dosing targets and require external validation.\n\nTrial Registration: Chinese Clinical Trial Registry, ChiCTR2600121464; prospectively registered March 31, 2026.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, 550004, People’s Republic of China"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaofen Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing Wan",
      "orcid": "0009-0000-6941-0225"
    },
    {
      "affs": [
        0
      ],
      "name": "Ruwen Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Rui Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Mengrong Hu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dwqc47qscw32r.bib",
  "cited_by": 0,
  "doi": "10.2147/dddt.s658705",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738090/",
  "id": "dwqc47qscw32r",
  "issns": [
    "1177-8881"
  ],
  "landing_url": "https://doi.org/10.2147/dddt.s658705",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Trial Report"
    ],
    [
      "openalex",
      "2703|Anesthesia and Sedative Agents"
    ]
  ],
  "openalex": "W7224993201",
  "pdf_url": "https://www.dovepress.com/article/download/121682",
  "pmcid": "PMC13738090",
  "pmid": "42992127",
  "published": "2026-11-01",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/dwqc47qscw32r.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:08Z",
      "native_id": "PMC13738090",
      "source": "pmc",
      "url": "https://doi.org/10.2147/dddt.s658705"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2703|Anesthesia and Sedative Agents",
      "subfield": "surgery"
    }
  ],
  "title": "Pump-Predicted Ciprofol Ce50 for Suppressing the Cardiovascular Response to Tracheal Intubation During Fixed Sufentanil–Esketamine Induction: An Age-Stratified Dixon Up-and-Down Study",
  "title_text": "Pump-Predicted Ciprofol Ce50 for Suppressing the Cardiovascular Response to Tracheal Intubation During Fixed Sufentanil–Esketamine Induction: An Age-Stratified Dixon Up-and-Down Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:08Z",
  "url": "https://research.draconitic.com/paper/dwqc47qscw32r",
  "venue": "Drug Design, Development and Therapy",
  "versions": []
}