{
  "abstract": "Purpose: Pancreatitis in patients with hematologic malignancies, particularly lymphoma, is a challenging complication with heterogeneous etiologies. Large studies with systematic etiological classification and prognostic models are lacking.\n\nMethods: This retrospective multicenter study (2020–2025) included patients with hematologic malignancies who developed acute pancreatitis. Etiologies were adjudicated using predefined criteria. A nomogram-based prediction model was developed with internal bootstrap validation.\n\nResults: Among 1,705 patients, 31 (1.82%) developed pancreatitis: 19 lymphoma (61.3%), 9 leukemia (29.0%), and 3 plasma cell disorders (9.7%). In the lymphoma cohort (median age 59 years, 57.9% male), diffuse large B-cell lymphoma (47.4%) and peripheral T-cell lymphoma (PTCL) (21.1%) were most common. Etiology distribution: treatment-related (36.8%), direct pancreatic infiltration (31.6%), conventional (15.8%), multifactorial (10.5%), and infection-related (5.3%). Endoscopic ultrasound (EUS)-guided tissue acquisition had 83.3% diagnostic sensitivity for direct infiltration; positron emission tomography/computed tomography (PET-CT) showed a “tetrad sign” in 5/6 cases. Severe pancreatitis occurred in 21.1% of lymphoma-associated pancreatitis. The nomogram (incorporating time to pancreatitis ≤30 days, recent L-asparaginase (LAsp)/immune checkpoint inhibitors (ICIs) exposure, and absence of pancreatic mass) discriminated treatment-related from non-treatment-related etiologies with AUC 0.84 (95% CI 0.71–0.96). PTCL subtype (HR 3.12, 95% CI 1.28–7.61, p=0.012), multifactorial etiology (HR 2.56, 95% CI 1.02–6.42, p=0.045), and age ≥65 years (HR 2.01, 95% CI 0.95–4.25, p=0.07) predicted 1-year mortality (C-index 0.79).\n\nSummary: Lymphoma-associated pancreatitis is rare (1.8% of hematologic malignancies). Treatment-related causes slightly outnumber direct infiltration. EUS-guided tissue acquisition and PET-CT are valuable for differential diagnosis. The nomogram may assist etiological classification and risk stratification, but prospective validation is required.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Spleen and Stomach Disease, Yulin Traditional Chinese Medicine Hospital , , ,",
    "Health Science Center, Yangtze University , , ,",
    "Department of Hematology, The First Affiliated Hospital of Xi’an Jiao Tong University , , ,",
    "Department of Gastroenterology, Shaanxi Provincial People’s Hospital , , ,",
    "Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiao Tong University , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Juju Feng"
    },
    {
      "affs": [
        1
      ],
      "name": "Qiwei Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhiyi Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Tianjiao Duan"
    },
    {
      "affs": [
        4
      ],
      "name": "Aqian Zhao"
    },
    {
      "affs": [
        4
      ],
      "name": "Yanhui Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Linqing Sun"
    },
    {
      "affs": [
        4
      ],
      "name": "Yun Feng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dws4rk95n9szb.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1853848",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661464/?tool=EBI",
  "id": "dws4rk95n9szb",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13661464",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Pancreatitis Pathology and Treatment"
    ]
  ],
  "openalex": "W7214905551",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661464/pdf/?tool=EBI",
  "pmcid": "PMC13661464",
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/dws4rk95n9szb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:20Z",
      "native_id": "PMC:PMC13661464",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13661464"
    },
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1853848",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1853848/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Pancreatitis Pathology and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Lymphoma-associated pancreatitis: a multicenter retrospective cohort study with a prediction model",
  "title_text": "Lymphoma-associated pancreatitis: a multicenter retrospective cohort study with a prediction model",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:13Z",
  "url": "https://research.draconitic.com/paper/dws4rk95n9szb",
  "venue": "Frontiers in oncology",
  "versions": []
}