{
  "abstract": "Aluminium oxide (Al₂O₃) nanocomposites are increasingly emerging in modern engineering. However, there is still a significant gap in understanding how nanoarchitectonic design can be systematically combined with performance measures across different fields. The number of studies has examined individual functionalities; there is still a lack of a clear and integrated framework that connects synthesis strategies with the optimization of material properties for applications in heat transfer, environmental remediation and biomedical systems. This review brings together recent advances by examining how processing methods influence structural development and in turn, affect interfacial interactions and material performance. We examine how different fabrication methods, including sol-gel, hydrothermal synthesis, and emerging cold sintering techniques, influence key material characteristics such as phase composition (α- and γ-Al₂O₃), dispersion stability and thermal resistance at interfaces. The analysis shows that the shift from simply improving mechanical strength to achieving multifunctional performance depends largely on how the Al₂O₃ phase is carefully distributed and integrated within the host matrix. The findings also highlight the important role of interface engineering in improving thermal conductivity in nanofluids, accelerating adsorption during wastewater treatment and enhancing controlled bioactivity in drug delivery systems. We also examine the key challenges in moving these materials toward practical applications, particularly nanoparticle agglomeration and potential toxicity. The review further emphasizes the need for cradle-to-gate life-cycle assessments (LCA) to determine whether proposed synthesis methods can genuinely be considered environmentally sustainable. By taking an integrated approach that connects processing, structure, properties and performance, this review highlights data-driven nanoarchitectonic and scalable in situ synthesis as two key priorities for future research. Overall, Al₂O₃ nanocomposites offer strong potential for developing more sustainable technologies. However, their successful application will depend on better control of interfacial properties, along with careful consideration of environmental safety and the development of standardized methods that can be reliably applied at an industrial scale.",
  "abstract_shown": true,
  "affiliations": [
    "Nanotechnology and Catalysis Center, Institute for Advanced Studies, Universiti Malaya Malaysia zaira.chowdhury76@gmail.com.",
    "Department of Mechanical Engineering, Faculty of Engineering, Universiti Malaya Malaysia.",
    "Nano Optoelectronics Research and Technology (INOR), Universiti Sains Malaysia 11800 Penang Malaysia.",
    "Sunway Centre for Electrochemical Energy and Sustainable Technology, Faculty of Engineering and Technology, Sunway University, Jalan University No. 5, Bandar Sunway 47500 Subang Jaya Selangor Malaysia."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Iftikhar Fareed",
      "orcid": "0000-0002-9571-2267"
    },
    {
      "affs": [
        0
      ],
      "name": "Zaira Zaman Chowdhury"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohd Rafie Bin Johan"
    },
    {
      "affs": [
        1
      ],
      "name": "Kazi Md Salim Newaz",
      "orcid": "0000-0002-8267-1371"
    },
    {
      "affs": [
        1
      ],
      "name": "Mohd Nashrul Mohd Zubir"
    },
    {
      "affs": [
        1
      ],
      "name": "Rab Nawaz",
      "orcid": "0009-0007-1725-3038"
    },
    {
      "affs": [
        1
      ],
      "name": "Muhammad Asif Awan"
    },
    {
      "affs": [
        2
      ],
      "name": "Syed Tawab Shah",
      "orcid": "0000-0002-8481-3003"
    },
    {
      "affs": [
        3
      ],
      "name": "Arshid Numan",
      "orcid": "0000-0003-1690-2001"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dwtmzmd64qa7x.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra08056a",
  "fulltext_url": "https://europepmc.org/articles/PMC13692718",
  "id": "dwtmzmd64qa7x",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42921297",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2503|Advanced ceramic materials synthesis"
    ]
  ],
  "openalex": "W7223303852",
  "pdf_url": "https://europepmc.org/articles/PMC13692718?pdf=render",
  "pmcid": "PMC13692718",
  "pmid": "42921297",
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dwtmzmd64qa7x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42921297",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42921297"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2503|Advanced ceramic materials synthesis",
      "subfield": "materials-polymers"
    }
  ],
  "title": "A comprehensive review on multi-functional Al₂O₃ nanocomposites: synthesis, properties and emerging applications in heat transfer, environmental remediation and biomedical systems.",
  "title_text": "A comprehensive review on multi-functional Al₂O₃ nanocomposites: synthesis, properties and emerging applications in heat transfer, environmental remediation and biomedical systems.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/dwtmzmd64qa7x",
  "venue": "RSC advances",
  "versions": []
}