{
  "abstract": "Advanced Head and Neck Squamous Cell Carcinomas (HNSCCs) pose a significant clinical challenge due to their poor survival rates. The DNA damage response (DDR) pathway plays a crucial role in the progression and treatment of advanced HNSCC, prompting the need to identify the underlying molecular mechanisms and develop innovative therapeutic strategies. One promising candidate is the RAD52 motif-containing protein 1 (RDM1), which functions as a regulator of DDR and exhibits context-dependent roles in tumorigenesis. However, the precise function and molecular mechanism of RDM1 in HNSCC remain poorly understood. In our study, we observed a relatively high expression of RDM1 in HNSCC tumor tissues. Functional experiments revealed that RDM1 contributed to increased cell proliferation and suppressed apoptosis in HNSCC cells, indicating its oncogenic role in HNSCC development. By modulating the levels of RAD52/TP53 and CDKN1A/CDK6 proteins, RDM1 played a critical role in regulating DDR and the cell cycle in HNSCC cells. Additionally, our investigations uncovered a novel role of RDM1 in the antioxidant response, wherein it facilitated the accumulation of NRF2 proteins. Interestingly, we found that RDM1 interacted with KEAP1 protein to promote NRF2 accumulation, ultimately promoting HNSCC progression. These findings establish the oncogenic role of RDM1 in HNSCC and emphasize the novel RDM1-KEAP1-NRF2 axis as a mechanism underlying the antioxidant response. They also highlight the potential of RDM1 as a therapeutic target for HNSCC, while its prognostic value warrants further validation in larger independent cohorts.",
  "abstract_shown": true,
  "affiliations": [
    "Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China",
    "Department of Geriatrics, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China",
    "Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China",
    "Department of Otolaryngology Guangdong Provincial Key Laboratory of Intelligent Port Security Inspection, Guangzhou, Guangdong, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fengpin Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jie Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Wenjie Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ruilin Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yunqi Mao"
    },
    {
      "affs": [
        2
      ],
      "name": "Fuhan Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Yixuan Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Pingjiang Ge"
    },
    {
      "affs": [
        0
      ],
      "name": "Weiqun Zhu"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiaodong Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanfang Zheng"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhongming Lu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dwv2bk14mh8hp.bib",
  "cited_by": 0,
  "doi": "10.3389/fmolb.2026.1944888",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710011/",
  "id": "dwv2bk14mh8hp",
  "issns": [
    "2296-889X"
  ],
  "landing_url": "https://doi.org/10.3389/fmolb.2026.1944888",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7221728247",
  "pdf_url": "https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2026.1944888/pdf",
  "pmcid": "PMC13710011",
  "pmid": "42947746",
  "published": "2026-10-13",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/dwv2bk14mh8hp.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:03Z",
      "native_id": "PMC13710011",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmolb.2026.1944888"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "journal-openalex:1312|Protein Structure and Dynamics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Unraveling the role of RDM1 in head and neck squamous cell carcinoma: insights into DDR regulation and antioxidant response",
  "title_text": "Unraveling the role of RDM1 in head and neck squamous cell carcinoma: insights into DDR regulation and antioxidant response",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:03Z",
  "url": "https://research.draconitic.com/paper/dwv2bk14mh8hp",
  "venue": "Frontiers in Molecular Biosciences",
  "versions": []
}