{
  "abstract": "Plants have evolved complex phytochemical and immune defense mechanisms in response to pathogen invasion. Plants deploy phytochemical defense system—signaling molecules, secondary metabolites, antimicrobial proteins and peptides—to mitigate the pathogens they encounter. Pathogens have developed strategies—effector proteins, efflux pumps and detoxification mechanisms—to manipulate or overcome plant defenses. This review offers insights into how these bioactive compounds are biosynthesized and activated following pathogen recognition. We provide an overview of the dynamic crosstalk between PTI and ETI and their role in optimizing plant defense. Additionally, we discuss the potential of advanced genetic engineering approaches, nanocarrier-mediated elicitor delivery, and microbiome engineering to enhance these natural defenses. Finally, we address the technical bottlenecks of engineering plant immunity and provide a roadmap for future research directions. This review provides a stronger mechanistic foundation for breeding crops with durable, broad-spectrum resilience for sustainable crop protection.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Tai’an, 271018 China",
    "College of Agronomy, Shandong Agricultural University, Tai’an, Shandong 271018 China",
    "Department of Biochemistry, Government College Women University, Faisalabad, 38000 Pakistan",
    "State Key Laboratory of Wheat Improvement, Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agriculture Sciences in Weifang, Weifang, Shandong 261325 China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Muhammad Zunair Latif"
    },
    {
      "affs": [
        0
      ],
      "name": "Miaomiao Deng"
    },
    {
      "affs": [
        1
      ],
      "name": "Naila Asghar"
    },
    {
      "affs": [
        0
      ],
      "name": "Lingguang Kong"
    },
    {
      "affs": [
        2
      ],
      "name": "Sumaira Kousar"
    },
    {
      "affs": [
        0
      ],
      "name": "Haimiao Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Shams Ur Rehman"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanke Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Muhammad Humza"
    },
    {
      "affs": [
        0
      ],
      "name": "ChongChong Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinhua Ding",
      "orcid": "0000-0002-6510-5992"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dww5v24ezdace.bib",
  "cited_by": 0,
  "doi": "10.1007/s44154-026-00343-z",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710501/",
  "id": "dww5v24ezdace",
  "issns": [
    "2097-4418",
    "2731-0450"
  ],
  "landing_url": "https://doi.org/10.1007/s44154-026-00343-z",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1110|Plant-Microbe Interactions and Immunity"
    ]
  ],
  "openalex": "W7223662751",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s44154-026-00343-z.pdf",
  "pmcid": "PMC13710501",
  "pmid": "42932096",
  "published": "2026-10-26",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/dww5v24ezdace.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:27Z",
      "native_id": "PMC13710501",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s44154-026-00343-z"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant-Microbe Interactions and Immunity",
      "subfield": "plant-biology"
    }
  ],
  "title": "Plant resilience: harnessing bioactive compounds for sustainable disease protection",
  "title_text": "Plant resilience: harnessing bioactive compounds for sustainable disease protection",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:27Z",
  "url": "https://research.draconitic.com/paper/dww5v24ezdace",
  "venue": "Stress Biology",
  "versions": []
}