{
  "abstract": "Background:: Additional tests are often requested on previously collected and stored samples. Automated storage and retrieval modules (SRMs) which are integrated into total laboratory automation (TLA) systems provide sealed, temperature-controlled storage and could potentially extend the scope of add-on testing. However, there is a lack of data regarding the stability of immunoassays when using an automated SRM. Methods:: We evaluated the short-term stability of 17 immunoassay analytes. Fresh serum and plasma samples were analysed using the Atellica IM (Siemens Healthineers) system at baseline and after storage in the SRM at 2-8 • C for 24, 48, and 72 h. Stability was assessed as the mean percentage change compared to the total limit of change (TLC), derived from analytical and biological variability. Results:: Most analytes remained stable for up to 72 h in both matrices. No significant differences were observed between serum and plasma, except for free T4, which exceeded its TLC in plasma after 72 h (+9.2%).\n\nConclusions:: This study demonstrates that most clinical immunoassays assessed on the Atellica IM module remained stable for up to 72 h in serum and plasma when stored in an automated SRM environment, except for free T4, which remained stable for up to 48 h in plasma. These findings support the feasibility and safety of performing delayed add-on tests in laboratories using TLA.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Mohammed Bouriche"
    },
    {
      "name": "Cyril Leven"
    },
    {
      "name": "Hélène Kerspern"
    },
    {
      "name": "Emmanuelle Plee-Gautier"
    },
    {
      "name": "Clément Capaldo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dwyzvbnbp87tk.bib",
  "cited_by": 1,
  "doi": "10.1016/j.clinbiochem.2026.111121",
  "fulltext_url": null,
  "id": "dwyzvbnbp87tk",
  "issns": [
    "0009-9120",
    "1873-2933"
  ],
  "landing_url": "https://univ-brest.hal.science/hal-05732249v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2737|Clinical Laboratory Practices and Quality Control"
    ]
  ],
  "openalex": "W7142156654",
  "pdf_url": "https://univ-brest.hal.science/hal-05732249/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-31",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/dwyzvbnbp87tk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "hal-05732249",
      "source": "hal",
      "url": "https://univ-brest.hal.science/hal-05732249v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Clinical Laboratory Practices and Quality Control",
      "subfield": "physiology"
    }
  ],
  "title": "Stability study of 17 clinical immunoassays analytes in serum and plasma samples within an automated storage and retrieval module: Assessment of add-on testing policies",
  "title_text": "Stability study of 17 clinical immunoassays analytes in serum and plasma samples within an automated storage and retrieval module: Assessment of add-on testing policies",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/dwyzvbnbp87tk",
  "venue": "Clinical Biochemistry",
  "versions": []
}