{
  "abstract": "This study reports an optimized method for the synthesis of spiro-1,2-dihydropyridines via the cycloisomerization of 3-aza-1,5-enynes, catalyzed by heterogeneous gold(I)–polyoxometalate (POM) hybrids. By replacing traditional homogeneous catalysts with these hybrid systems, we achieved high yields (up to 82% isolated) in short reaction times, while minimizing product degradation. The reaction scope was demonstrated across a broad range of substrates, including aryl, alkyl, and heterocyclic derivatives, as well as variations in ring size and nitrogen substituents using 5 mol % of [AuI(IPr)(MeCN)][H₅P₂W₁₈O₆₄] as catalyst.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Titien Simon"
    },
    {
      "name": "Fabian Schlimpen"
    },
    {
      "name": "Pierre de Frémont"
    },
    {
      "name": "Stefan Chassaing"
    },
    {
      "name": "Aurélien Blanc"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dx4pmbm6r8cjb.bib",
  "cited_by": 0,
  "doi": "10.3762/bjoc.22.106",
  "fulltext_url": null,
  "id": "dx4pmbm6r8cjb",
  "issns": [
    "1860-5397"
  ],
  "landing_url": "https://hal.science/hal-05768292v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.cata"
    ],
    [
      "hal",
      "1.chim.orga"
    ],
    [
      "openalex",
      "1605|Catalytic Alkyne Reactions"
    ]
  ],
  "openalex": "W7214651978",
  "pdf_url": "https://hal.science/hal-05768292/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-28",
  "publisher": "Beilstein-Institut",
  "ris": "https://research.draconitic.com/paper/dx4pmbm6r8cjb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:42Z",
      "native_id": "hal-05768292",
      "source": "hal",
      "url": "https://hal.science/hal-05768292v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.cata",
      "subfield": "catalysis"
    },
    {
      "field": "chemistry",
      "origin": "hal:1.chim.orga",
      "subfield": "organic"
    }
  ],
  "title": "Synthesis of spiro-1,2-dihydropyridine derivatives via cycloisomerization of 3-aza-1,5-enynes catalyzed by gold(I) complex/polyoxometalate hybrids",
  "title_text": "Synthesis of spiro-1,2-dihydropyridine derivatives via cycloisomerization of 3-aza-1,5-enynes catalyzed by gold(I) complex/polyoxometalate hybrids",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:42Z",
  "url": "https://research.draconitic.com/paper/dx4pmbm6r8cjb",
  "venue": "Beilstein Journal of Organic Chemistry",
  "versions": []
}