{
  "abstract": "Anaemia remains a major public health challenge among adolescents, particularly in low- and middle-income countries. This narrative review evaluates adolescent anaemia as a candidate marker of cardiometabolic vulnerability within a life-course preventive cardiology framework. Targeted searches considered literature available through August 2026, distinguishing anaemia, iron deficiency and iron deficiency anaemia and separating direct adolescent evidence from adult and mechanistic extrapolation. Impaired oxygen delivery, iron-dependent mitochondrial dysfunction, altered glucose metabolism, inflammation, endothelial dysfunction and reduced functional capacity provide biologically plausible pathways. Direct adolescent evidence mainly concerns short-term functional outcomes; prospective evidence linking adolescent anaemia with adult cardiometabolic disease remains limited. Iron-metabolic relationships may be nonlinear and bidirectional, while iron deficiency anaemia can alter glycated haemoglobin independently of glycaemia. Adult heart-failure trials support selected clinical benefits of intravenous iron, although contemporary outcome trials are mixed and mortality benefit remains uncertain. Shared nutritional, inflammatory and socioeconomic determinants may also explain observed associations. Current clinical implications include aetiological assessment and treatment of anaemia, nutritional optimisation, menstrual health evaluation, physical activity promotion and cardiovascular risk assessment guided by established age- and risk-based indications. Prospective adolescent cohorts and intervention studies are needed to establish incremental predictive value and determine whether aetiology-specific treatment improves long-term cardiometabolic outcomes. This framework connects anaemia care with broader adolescent health promotion while defining the evidence needed for future preventive cardiology applications.",
  "abstract_shown": true,
  "affiliations": [
    "Sudhir Heart Centre, Berhampur, Odisha, India",
    "Great Eastern Medical School and Hospital, Srikakulam, Andhra Pradesh, India"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "D.S. Prasad"
    },
    {
      "affs": [
        1
      ],
      "name": "Sagarika Duggirala"
    },
    {
      "affs": [
        0
      ],
      "name": "Sailaja Duggirala"
    },
    {
      "affs": [
        0
      ],
      "name": "Revathi Devi Karuturi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dxaarwar8xqmr.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ahjo.2026.101002",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13753346/?tool=EBI",
  "id": "dxaarwar8xqmr",
  "issns": [
    "2666-6022"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13753346",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "2720|Iron Metabolism and Disorders"
    ]
  ],
  "openalex": "W7225016400",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13753346/pdf/?tool=EBI",
  "pmcid": "PMC13753346",
  "pmid": "43017495",
  "published": "2026-10-31",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/dxaarwar8xqmr.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:23:59Z",
      "native_id": "PMC:PMC13753346",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13753346"
    },
    {
      "first_seen": "2026-11-14T15:20:45Z",
      "native_id": "MED:43017495",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43017495"
    },
    {
      "first_seen": "2026-11-15T12:22:30Z",
      "native_id": "PMC13753346",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.ahjo.2026.101002"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2705|Heart Failure Treatment and Management",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Adolescent anaemia as a candidate marker of cardiometabolic vulnerability: A life-course preventive cardiology perspective",
  "title_text": "Adolescent anaemia as a candidate marker of cardiometabolic vulnerability: A life-course preventive cardiology perspective",
  "type": "peer-reviewed",
  "updated_at": "2026-11-15T12:22:30Z",
  "url": "https://research.draconitic.com/paper/dxaarwar8xqmr",
  "venue": "American heart journal plus : cardiology research and practice",
  "versions": []
}