{
  "abstract": "Chagas cardiomyopathy (ChCM) affects up to 30% of patients with chronic Chagas disease and lacks reliable biomarkers for severity and conduction abnormalities. We profiled cardiac autoantibodies using 2-dimensional gel electrophoresis and mass spectrometry, followed by enzyme-linked immunosorbent assay validation and machine learning analysis. Six autoantibodies linked to glycolysis, adenosine triphosphate metabolism, and sarcomere structure distinguished ChCM stages (area under the curve: 0.87; 95% CI: 0.777-0.977) and a mean classification accuracy (0.84; 95% CI: 0.705-0.935). These findings suggest that an antibody-based panel may enable cost-effective risk stratification and prognostication in ChCM, with prospective validation before clinical application.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Department of Pediatrics, The Labatt Family Heart Centre and Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.",
    "Department of Pediatrics, The Labatt Family Heart Centre and Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.",
    "Department of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.",
    "Department of Pediatrics, The Labatt Family Heart Centre and Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.",
    "Department of Infectious Disease, Tropical Medicine, University of São Paulo, São Paulo, SP, Brazil.",
    "Dante Pazzanese Institute of Cardiology, São Paulo, SP, Brazil.",
    "Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.",
    "Department of Congenital Heart Diseases, Cardinal Stefan Wyszyński National Institute of Cardiology, Warsaw, Poland.",
    "Arrhythmia Unit, Heart Institute (Institute Coração), University of São Paulo Medical School, São Paulo, Brazil.",
    "Laboratory of Genetics and Molecular Cardiology (LGMC), Heart Institute (Institute Coração), University of São Paulo Medical School, São Paulo, Brazil.",
    "Department of Internal Medicine, School of Medicine, Telehealth Center, Cardiology Service, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.",
    "Laboratory of Clinical Immunology and Allergy, Heart Institute (InCor), Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Institute of Investigation in Immunology, National Institute of Science and Technology (iii-INCT), São Paulo, Brazil.",
    "Institute of Parasitology, McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada; Division of Clinical and Translational Research, Department of Medicine, McGill University, Montreal, Quebec, Canada.",
    "Department of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Department of Pediatrics, The Labatt Family Heart Centre and Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: vivian.silbiger@sickkids.ca.",
    "Department of Pediatrics, The Labatt Family Heart Centre and Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: robert.hamilton@sickkids.ca."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 27,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Heriks Ribeiro"
    },
    {
      "affs": [
        1
      ],
      "name": "Anton Dmitriev"
    },
    {
      "affs": [
        2
      ],
      "name": "Antonia Pereira Rosa Neta"
    },
    {
      "affs": [
        3
      ],
      "name": "Meena Fatah"
    },
    {
      "affs": [
        3
      ],
      "name": "Diptendu Chatterjee"
    },
    {
      "affs": [
        4
      ],
      "name": "Lea Campos de Oliveira"
    },
    {
      "affs": [
        5
      ],
      "name": "Fabiano Castro Albrecht"
    },
    {
      "affs": [
        5
      ],
      "name": "Hui Tzu Lin Wang"
    },
    {
      "affs": [
        6
      ],
      "name": "Juliana de Assis S Gomes"
    },
    {
      "affs": [
        7
      ],
      "name": "Olgierd Woźniak"
    },
    {
      "affs": [
        7
      ],
      "name": "Karolina Borowiec"
    },
    {
      "affs": [
        7
      ],
      "name": "Elżbieta Katarzyna Biernacka"
    },
    {
      "affs": [
        2
      ],
      "name": "Antonia Claudia Jácome da Câmara"
    },
    {
      "affs": [
        8
      ],
      "name": "Luciana Sacilotto"
    },
    {
      "affs": [
        8
      ],
      "name": "Francisco Carlos da Costa Darrieux"
    },
    {
      "affs": [
        8
      ],
      "name": "Maurício Ibrahim Scanavacca"
    },
    {
      "affs": [
        9
      ],
      "name": "José Eduardo Krieger"
    },
    {
      "affs": [
        2
      ],
      "name": "Lúcia Maria da Cunha Galvão"
    },
    {
      "affs": [
        6
      ],
      "name": "Walderez Dutra"
    },
    {
      "affs": [
        10
      ],
      "name": "Antonio Luiz Pinho Ribeiro"
    },
    {
      "affs": [
        11
      ],
      "name": "Edecio Cunha-Neto"
    },
    {
      "affs": [
        10
      ],
      "name": "Maria Carmo Pereira Nunes"
    },
    {
      "affs": [
        4
      ],
      "name": "Ester Cerdeira Sabino"
    },
    {
      "affs": [
        12
      ],
      "name": "Igor Cestari"
    },
    {
      "affs": [
        2
      ],
      "name": "Andre Ducati Luchessi"
    },
    {
      "affs": [
        13
      ],
      "name": "Vivian Nogueira Silbiger"
    },
    {
      "affs": [
        14
      ],
      "name": "Robert M Hamilton"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dxnymmqb68cn9.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jacbts.2026.101709",
  "fulltext_url": "https://europepmc.org/articles/PMC13677190",
  "id": "dxnymmqb68cn9",
  "issns": [
    "2452-302X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42854667",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Trypanosoma species research and implications"
    ]
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  "openalex": "W7221174813",
  "pdf_url": "https://europepmc.org/articles/PMC13677190?pdf=render",
  "pmcid": "PMC13677190",
  "pmid": "42854667",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dxnymmqb68cn9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:12Z",
      "native_id": "MED:42854667",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42854667"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Trypanosoma species research and implications",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Identifying Cardiac Autoantibody Biomarkers that Predict the Severity of Chagas Cardiomyopathy.",
  "title_text": "Identifying Cardiac Autoantibody Biomarkers that Predict the Severity of Chagas Cardiomyopathy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:12Z",
  "url": "https://research.draconitic.com/paper/dxnymmqb68cn9",
  "venue": "JACC. Basic to translational science",
  "versions": []
}