{
  "abstract": "Objective: To compare serum DPPX levels between epilepsy patients and healthy controls, evaluate its diagnostic performance via ROC analysis, and assess associations with disease duration.\n\nMethods: A hospital-based case-control study (Nov 2025–Mar 2026) included 50 epilepsy patients (18–75 years, both sexes, ≥1 year of aware/impaired awareness seizures) and 50 age-/sex-matched healthy controls. Exclusion criteria: diabetes, chronic diseases, autoimmune disorders, cancer, pregnancy, lactation. Serum DPPX measured by ELISA. Statistical analysis used SPSS v26 (t-test, chi-square, ROC). Significance: p≤0.05.\n\nResults: Mean age was similar between patients (33.24±8.31 years) and controls (32.18±7.11 years; p=0.681). Serum DPPX was significantly lower in epilepsy patients (47.02±4.33 vs. 83.68±7.38 ng/mL; p=0.001). ROC analysis yielded an optimal cut-off <46.69 ng/mL (AUC=0.721, 95% CI: 0.623–0.819; p=0.001), sensitivity 70.0%, specificity 74.0%, PPV 72.9%, NPV 71.2%. No significant DPPX difference between disease duration ≤10 years (45.16±6.48 ng/mL) and >10 years (48.49±5.92 ng/mL; p=0.707).\n\nConclusion: Serum DPPX is significantly reduced in epilepsy patients, showing modest discriminatory value that remains stable across disease duration. It may serve as a potential adjunct biomarker. Larger prospective studies with epilepsy subtype stratification are warranted.",
  "abstract_shown": true,
  "affiliations": [
    "Ministry of Health – Al Diwaniyah, Al Diwaniyah, Iraq",
    "Al Furat Al Awsat Technical University, Kufa, Iraq"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ahmed Hussein"
    },
    {
      "affs": [
        1
      ],
      "name": "Salim Hassan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dygke6r9eb69c.bib",
  "cited_by": 0,
  "doi": "10.38029/babcockuniv.med.j..v9is1.1581",
  "fulltext_url": "https://bumj.babcock.edu.ng/index.php/bumj/article/view/1581",
  "id": "dygke6r9eb69c",
  "issns": [
    "2465-6666",
    "2756-4657"
  ],
  "landing_url": "https://doi.org/10.38029/babcockuniv.med.j..v9is1.1581",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Babcock Medical Society",
  "ris": "https://research.draconitic.com/paper/dygke6r9eb69c.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T14:21:03Z",
      "native_id": "0e7607b597bb4a8bbdfecf3cb90e44af",
      "source": "doaj",
      "url": "https://doi.org/10.38029/babcockuniv.med.j..v9is1.1581"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:R",
      "subfield": "general"
    }
  ],
  "title": "Evaluation of serum dipeptidyl-peptidase-like protein 6 (dppx) levels in patients with epilepsy: a case control study from Al Diwaniyah governorate, Iraq",
  "title_text": "Evaluation of serum dipeptidyl-peptidase-like protein 6 (dppx) levels in patients with epilepsy: a case control study from Al Diwaniyah governorate, Iraq",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T14:20:29Z",
  "url": "https://research.draconitic.com/paper/dygke6r9eb69c",
  "venue": "Babcock University Medical Journal",
  "versions": []
}