{
  "abstract": "The cochlea lies within marrow-bearing bone. How this neighbouring marrow relates to cochlear immunity and daily physiology remains poorly resolved. We profiled 160,643 cells from mouse cochlea and adjacent temporal-bone marrow at six times of day, with rhythm inference calibrated for one pooled sample per time. Three-dimensional confocal reconstruction mapped vascular connections between marrow and cochlea and localized neutrophils along this interface. Neutrophils also occupied healthy cochlear fluids. Parabiosis findings were consistent with a local marrow contribution to cochlear immunity. Structural cochlear cells maintained synchronized, light-entrained clocks. Cochlear neutrophil programmes aligned with circulating neutrophils and opposed those in marrow, with independent flow cytometry supporting daily changes in immune composition and CXCR4. A shared night-associated heat-shock programme was attenuated after noise in an independent cohort. These anatomical and temporal data provide a reference for testing local marrow supply and the origins of cochlear immune rhythms.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otorhinolaryngology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong, China; Guangdong Provincial Key Laboratory"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "H. Wang"
    },
    {
      "name": "J. Yeong"
    },
    {
      "name": "Y. Cai"
    },
    {
      "name": "Y. Mo"
    },
    {
      "affs": [
        0
      ],
      "name": "Y. Tian"
    },
    {
      "name": "W. Chen"
    },
    {
      "name": "D. Zeng"
    },
    {
      "name": "H. Ning"
    },
    {
      "name": "Y. Xu"
    },
    {
      "name": "S. Dai"
    },
    {
      "name": "X. Liu"
    },
    {
      "name": "R. He"
    },
    {
      "name": "H. Liu"
    },
    {
      "name": "J. Huang"
    },
    {
      "name": "J. Hao"
    },
    {
      "name": "Y. Ni"
    },
    {
      "affs": [
        0
      ],
      "name": "C. Tian"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dyy6capgwnpb0.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.31.763358",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.31.763358v1.full",
  "id": "dyy6capgwnpb0",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.31.763358v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.31.763358v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dyy6capgwnpb0.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:27:11Z",
      "native_id": "10.64898/2026.10.31.763358",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.31.763358v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "An anatomical and day-night atlas links cochlear immunity to adjacent bone marrow",
  "title_text": "An anatomical and day-night atlas links cochlear immunity to adjacent bone marrow",
  "type": "preprint",
  "updated_at": "2026-11-10T00:27:11Z",
  "url": "https://research.draconitic.com/paper/dyy6capgwnpb0",
  "venue": "bioRxiv",
  "versions": []
}