{
  "abstract": "Background\n\nCirculating eosinophils can be measured inexpensively and reproducibly in routine care. Beyond their role in parasite defense and allergy, blood eosinophilia is now a key biomarker in respiratory medicine: prognostic, predictive, and recognized as a \"treatable trait.\" Its role as a marker of susceptibility, however, is not well defined.Methods\n\nWe conducted a monocentric retrospective hospital-based cohort study at Montpellier University Hospital (France), including all adults hospitalized in 2018 with a complete blood count and without prior respiratory disease. Eosinophil counts were stratified as < 150/mm³, 150-299/mm³, and ≥ 300/mm³. The primary outcome was incident respiratory disease, defined by hospitalization with a respiratory diagnosis (ICD-10 J00-J99) or initiation of inhaled therapy (ATC R03). Follow-up extended to December 2024; secondary outcomes included diagnostic subcategories and ICU admission.Results\n\nAmong 24,405 patients, 6,173 (25.3%) developed incident respiratory disease. Event rates followed a dose-response pattern across eosinophil strata: 21.7% (< 150/mm³), 26.0% (150-299/mm³), and 32.9% (≥ 300/mm³; p < 0.001 pairwise comparisons across all groups). After multivariable adjustment, eosinophilia remained independently associated with higher risk of developing respiratory disease (HR 1.45, 95% CI 1.35-1.55). Baseline eosinophilia was also associated to increased ICU admissions and greater disease severity during the follow-up.Conclusion\n\nBlood eosinophilia was strongly associated with both increased risk of developing incident respiratory disease and in-hospital severity, in a clear dose-response manner. However, most patients with high counts (> 300/mm3) did not develop respiratory events, underscoring the need to integrate blood eosinophil counts with complementary clinical and biological data for risk stratification.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory Diseases, CHU Montpellier, Arnaud de Villeneuve Hospital, Montpellier, 34000, France.",
    "PhyMedExp INSERM 1046, UMR UM, CNRS 9214, University of Montpellier, Montpellier, 34000, France.",
    "Clinical Research and Epidemiology Unit (Public Health Department), CHU Montpellier, Univ Montpellier, Montpellier Cedex 5, France.",
    "Pathogenesis and Control of Chronic Infections, University of Montpellier, INSERM, Etablissement Français du Sang, Montpellier, France.",
    "Department of Virology, Montpellier University Hospital, Montpellier, France.",
    "Institut Desbrest d'Épidémiologie et de Santé Publique, Univ Montpellier- INSERM - INRIA PreMediCal, Montpellier, France.",
    "Division of Medical Information, La Colombiere University Hospital of Montpellier, Montpellier, France.",
    "Department of Respiratory Diseases, CHU Montpellier, Arnaud de Villeneuve Hospital, Montpellier, 34000, France. engi.ahmed@chu-montpellier.fr.",
    "PhyMedExp INSERM 1046, UMR UM, CNRS 9214, University of Montpellier, Montpellier, 34000, France. engi.ahmed@chu-montpellier.fr."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Charles Roure"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jeremy Charriot"
    },
    {
      "affs": [
        1
      ],
      "name": "Dany Jaffuel"
    },
    {
      "affs": [
        2
      ],
      "name": "Erika Nogue"
    },
    {
      "affs": [
        2
      ],
      "name": "Manal Ahikki"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Edouard Tuaillon"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Nicolas Molinari"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Arnaud Bourdin"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Engi Ahmed"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dz0z67d324hyc.bib",
  "cited_by": 0,
  "doi": "10.1186/s12931-026-03851-8",
  "fulltext_url": "https://europepmc.org/articles/PMC13721206",
  "id": "dz0z67d324hyc",
  "issns": [
    "1465-9921",
    "1465-993X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958569",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2737|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W7172455502",
  "pdf_url": "https://europepmc.org/articles/PMC13721206?pdf=render",
  "pmcid": "PMC13721206",
  "pmid": "42958569",
  "published": "2026-08-04",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/dz0z67d324hyc.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:29Z",
      "native_id": "MED:42958569",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958569"
    },
    {
      "first_seen": "2026-11-03T12:21:56Z",
      "native_id": "PMC13721206",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12931-026-03851-8"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Asthma and respiratory diseases",
      "subfield": "physiology"
    }
  ],
  "title": "Blood eosinophilia as a susceptibility biomarker for incident respiratory disease in hospitalized adults: a retrospective cohort study.",
  "title_text": "Blood eosinophilia as a susceptibility biomarker for incident respiratory disease in hospitalized adults: a retrospective cohort study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:56Z",
  "url": "https://research.draconitic.com/paper/dz0z67d324hyc",
  "venue": "Respiratory research",
  "versions": []
}