{
  "abstract": "Lycopene is a bioactive carotenoid whose application is limited by poor aqueous dispersibility and susceptibility to degradation. Redispersible lycopene nanoparticles were prepared by solvent displacement-evaporation followed by freeze-drying, and interfacial composition and nominal lycopene fraction were evaluated sequentially. Among the tested interfacial compositions, a 2 : 1 Tween 80/phosphatidylcholine mass ratio produced the smallest particles and lowest dispersity. At this ratio, the formulation containing 12 wt% nominal lycopene was selected for its balance of lycopene content, particle size, and dispersity. The measured lycopene content of the freeze-dried formulation was 11.63 wt%; after aqueous redispersion, the particles exhibited a mean hydrodynamic diameter of 133.25 ± 1.46 nm, a polydispersity index of 0.173 ± 0.016, and a zeta potential of -38.3 ± 1.9 mV. TEM showed predominantly near-spherical particles. FTIR spectra were consistent with physical incorporation in the matrix, while XRD showed marked attenuation of crystalline lycopene reflections. The redispersed formulation maintained its colloidal characteristics for 7 days at 4 °C, and the freeze-dried formulation retained 91.9% of its initial lycopene content after 180 days at -20 °C. At matched lycopene doses, the formulation showed higher apparent DPPH radical-scavenging activity and greater protection against H₂O₂-induced loss of HepG2 cell viability than free lycopene. It also inhibited oleic acid-induced intracellular lipid accumulation by 89.1% at the highest dose versus 68.0% for free lycopene, while cell viability remained above 90%. Overall, sequential evaluation of interfacial composition and nominal lycopene fraction yielded a redispersible freeze-dried formulation combining controlled colloidal properties, storage stability, and improved in vitro functional performance.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Chemistry, Vietnam Academy of Science and Technology 18 Hoang Quoc Viet, Nghia Do Ward Hanoi 10000 Vietnam hoangmaiha@ich.vast.vn.",
    "Graduate University of Science and Technology, Vietnam Academy of Science and Technology 18 Hoang Quoc Viet, Nghia Do Ward Hanoi 10000 Vietnam."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ho Thi Oanh",
      "orcid": "0000-0001-9036-2029"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hong Tham Nguyen",
      "orcid": "0009-0009-5437-3906"
    },
    {
      "affs": [
        0
      ],
      "name": "Nguyen Phu Duc",
      "orcid": "0009-0001-4485-939X"
    },
    {
      "affs": [
        0
      ],
      "name": "Nhung Hac Thi",
      "orcid": "0000-0003-1474-6404"
    },
    {
      "affs": [
        0
      ],
      "name": "Dinh Dung Luong",
      "orcid": "0009-0005-5053-6430"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mai Ha Hoang",
      "orcid": "0000-0002-1401-6754"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dz925vk9cfz7h.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra08147a",
  "fulltext_url": "https://europepmc.org/articles/PMC13678499",
  "id": "dz925vk9cfz7h",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898975",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1106|Proteins in Food Systems"
    ]
  ],
  "openalex": "W7222934429",
  "pdf_url": "https://europepmc.org/articles/PMC13678499?pdf=render",
  "pmcid": "PMC13678499",
  "pmid": "42898975",
  "published": "2026-10-19",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/dz925vk9cfz7h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42898975",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898975"
    },
    {
      "first_seen": "2026-11-07T12:23:33Z",
      "native_id": "PMC13678499",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra08147a"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "heading:Chemistry",
      "subfield": "general"
    }
  ],
  "title": "Formulation-dependent colloidal properties of redispersible lycopene nanoparticles: storage stability and enhanced in vitro bioactivity.",
  "title_text": "Formulation-dependent colloidal properties of redispersible lycopene nanoparticles: storage stability and enhanced in vitro bioactivity.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:02Z",
  "url": "https://research.draconitic.com/paper/dz925vk9cfz7h",
  "venue": "RSC advances",
  "versions": []
}