{
  "abstract": "Background: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and impaired glucocorticoid sensitivity may contribute to the inflammatory and metabolic abnormalities observed in schizophrenia (SZ), including metabolic syndrome (MetS), a major contributor to excess morbidity and premature mortality. However, the contribution of glucocorticoid response-related genetic variants to these abnormalities remains underexplored.\n\nMethod: Two hundred and sixty-one patients with SZ were genotyped for two NR3C1 polymorphisms (rs41423247, G > C and rs6198, T > C) and one GLCCI1 polymorphism (rs37972, C > T). Logistic regression analyses were used to assess associations between genotypes and inflammation, evaluated by high-sensitivity C-reactive protein (hsCRP), and clinical features, including early-onset SZ (EOS), treatment-resistant SZ (TRS), suicidal attempts (SA) and MetS. Mediation analysis was used to evaluate the role of inflammation in genotype-MetS associations.\n\nResults: No significant association was observed between NR3C1 polymorphisms and outcomes studied. In contrast, multivariate analysis showed that the GLCCI1 rs37972 TT genotype was significantly associated with an increased likelihood of inflammation and MetS compared with TC/CC genotypes (inflammation: OR = 3.51, 95% CI 1.55-7.96, pFDR = 0.009; MetS: OR = 3.06, 95% CI 1.26-7.43, pFDR = 0.027). Additionally, mediation analysis revealed a significant indirect effect of the rs37972 TT genotype on MetS through inflammation, whereas the direct effect was not significant.\n\nConclusion: The GLCCI1 rs37972 polymorphism may be associated with altered glucocorticoid sensitivity, systemic inflammation, and MetS in SZ. These findings suggest a potential genetic-inflammatory pathway underlying the relationship between stress regulation and metabolic comorbidity in SZ. Given the cross-sectional design and the absence of a control group, the results should be considered exploratory and warrant replication in larger independent cohorts.",
  "abstract_shown": true,
  "affiliations": [
    "Univ Paris Est Créteil (UPEC), INSERM U955, IMRB, Translational Neuropsychiatry, Créteil, F-94010, France",
    "Fondation FondaMental, Créteil, 94000, France",
    "AP-HP, Hôpitaux Universitaires Henri Mondor, Département Médico-Universitaire de Psychiatrie et d’Addictologie (DMU IMPACT), Créteil, F-94010, France",
    "Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1, Inserm, Montpellier, 1061, France",
    "AP-HM, Service Universitaire de Psychiatrie et d'addictologie, Hôpital Sainte Marguerite, Marseille, 13009, France",
    "University Department of General Psychiatry, Charles Perrens Hospital, Bordeaux, F-33076, France",
    "Laboratory of Nutrition and Integrative Neurobiology (UMR INRA 1286), University of Bordeaux, Bordeaux, France",
    "Sorbonne Université, Inserm, CNRS, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Hôpital Pitié-Salpêtrière, Paris, France",
    "Division of Mental Health and Addiction, Centre for Precision Psychiatry, University of Oslo and Oslo University Hospital, Oslo, Norway",
    "Plateforme de Ressources Biologiques, AP-HP, Hôpitaux Universitaires Henri Mondor, Créteil, F94010, France",
    "Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada",
    "University of Clermont Auvergne, CMP-B CHU, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, F-63000, France",
    "Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM U1329, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France",
    "INSERM U1028, CNRS UMR5292, Centre de Recherche en Neurosciences de Lyon, Université Claude Bernard Lyon 1, Equipe PSYR2, Centre Hospitalier Le Vinatier, Pole Est, 95 bd Pinel, BP 30039, 69678 Bron Cedex, France",
    "AP-HP, Groupe Hospitalo-universitaire AP-HP Nord, DMU ESPRIT, Service de Psychiatrie et Addictologie, Hôpital Louis Mourier, Colombes, France",
    "Université de Paris Inserm UMR1266, Sorbonne Paris Cité, Faculté de Médecine, France",
    "Department of Psychiatry, University Hospital of Saint-Etienne, Saint-Etienne, France",
    "Department of Psychiatry, Psychotherapies, Art-therapy, Toulouse University Hospital, Equipe de Recherche sur les Rationalités Philosophiques et les Savoirs - EA3051, Université de Toulouse - Jean Jaurès, Toulouse, France",
    "Centre Référent de Réhabilitation Psychosociale et de Remédiation Cognitive (C3R), CH Alpes Isère, Bordeaux, France",
    "University of Bordeaux, Aquitaine Institute for Cognitive and Integrative Neuroscience (CNRS UMR 5287-INCIA), Bordeaux, France",
    "Department of Adult Psychiatry, Charles Perrens Hospital, Bordeaux, France",
    "Centre Hospitalier de Versailles, Service Universitaire de Psychiatrie d’Adultes et d’Addictologie, Le Chesnay, 78150, France",
    "MOODS Team, INSERM 1018, CESP, Université de Versailles Saint-Quentin-En-Yvelines, Université Paris Saclay, Orsay, 91400, France",
    "Service Universitaire de Psychiatrie, EPSM Loiret, CHU Orléans, Orléans, France",
    "Equipe BCLINE, Laboratoire Li2rso, Université d'Orléans, Orléans, France"
  ],
  "article_type": "research article",
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      "name": "Ching-Lien Wu"
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  "bibtex": "https://research.draconitic.com/paper/dzhssa1mnmdtp.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bbih.2026.101391",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737410/",
  "id": "dzhssa1mnmdtp",
  "issns": [
    "2666-3546"
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  "landing_url": "https://doi.org/10.1016/j.bbih.2026.101391",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Full Length Article"
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      "2738|Schizophrenia research and treatment"
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  "pmcid": "PMC13737410",
  "pmid": "42991995",
  "published": "2026-10-17",
  "publisher": "Elsevier",
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    {
      "first_seen": "2026-11-09T12:22:36Z",
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      "url": "https://doi.org/10.1016/j.bbih.2026.101391"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Schizophrenia research and treatment",
      "subfield": "psychiatry"
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  ],
  "title": "Mediating effect of inflammation on the association between glucocorticoid response-related polymorphism and metabolic syndrome in patients with schizophrenia: Evidence from the FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) cohort",
  "title_text": "Mediating effect of inflammation on the association between glucocorticoid response-related polymorphism and metabolic syndrome in patients with schizophrenia: Evidence from the FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:36Z",
  "url": "https://research.draconitic.com/paper/dzhssa1mnmdtp",
  "venue": "Brain, Behavior, & Immunity - Health",
  "versions": []
}