{
  "abstract": "Alzheimer’s disease (AD) represents a progressive neurodegenerative disorder that predominantly impairs the central nervous system. This study integrated single-cell RNA sequencing (scRNA-seq) and Mendelian randomization (MR) analysis to explore AD therapeutic targets and characterize alterations in immune cell infiltration and function. We analyzed the subtypes, developmental trajectories and intercellular communication of peripheral blood T cells from AD scRNA-seq data. Cell clustering identified CD8 + T cells as the key immune subpopulation in AD, with two vital intercellular communication pathways (MIF-(CD74 + CD44) and MIF-(CD74 + CXCR4)) identified by trajectory analysis. The expression quantitative trait loci (eQTL) data retrieved from the IEU OpenGWAS database were utilized to perform MR and colocalization analysis to evaluate the association between target genes and AD. Six multiple-SNP and one single-SNP potential target genes were screened via differential expression and MR analysis. Among these, dual-specificity phosphatase 2 (DUSP2) showed a suggestive but weak association with AD, with a mild positive correlation observed in sensitivity analyses. No statistically significant shared genetic signals were detected via colocalization analysis. Additionally, significant differences in intercellular communication were observed between DUSP2+IM and DUSP2-IM cells, with distinct activity across various communication pathways. Gene expression levels in the AD group were significantly higher than in healthy individuals (P = 0.01). In conclusion, this study identified CD8 + T cells as crucial factors in AD pathogenesis, while DUSP2 emerged as a suggestive candidate gene requiring further validation, providing novel mechanistic insights and potential therapeutic targets for AD treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Jiangxi Province Key Laboratory of Immunology and Inflammation, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China; Queen Mary College, Jiangxi Medical College, Nanchang University, Xuefu Road, Nanchang, Jiangxi, 330006, China",
    "Department of Biophysics and Neurology, Center for Membrane Receptors and Brain Medicine, The Fourth Affiliated Hospital of School of Medicine, And International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, China; Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, 310058, China",
    "Jiangxi Province Key Laboratory of Immunology and Inflammation, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China; The Second Clinical Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China",
    "Queen Mary College, Jiangxi Medical College, Nanchang University, Xuefu Road, Nanchang, Jiangxi, 330006, China",
    "The First Clinical Medical College, Nanchang University, Xuefu Road, Nanchang, Jiangxi, 330006, China",
    "Jiangxi Province Key Laboratory of Immunology and Inflammation, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China",
    "Jiangxi Province Key Laboratory of Immunology and Inflammation, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China; Corresponding author.",
    "Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, China; Corresponding author."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wanqian Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Min Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Xiajing Yu"
    },
    {
      "affs": [
        3
      ],
      "name": "Yun Hao"
    },
    {
      "affs": [
        4
      ],
      "name": "Zheng Fu"
    },
    {
      "affs": [
        2
      ],
      "name": "Linfeng Jin"
    },
    {
      "affs": [
        4
      ],
      "name": "Hui Liang"
    },
    {
      "affs": [
        5
      ],
      "name": "Kaili Liao"
    },
    {
      "affs": [
        6
      ],
      "name": "Xiaozhong Wang"
    },
    {
      "affs": [
        7
      ],
      "name": "Jiasheng Xu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dzk5rmp20x5m0.bib",
  "cited_by": 0,
  "doi": "10.1016/j.neurot.2026.e01092",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S187874792600262X",
  "id": "dzk5rmp20x5m0",
  "issns": [
    "1878-7479",
    "1933-7213"
  ],
  "landing_url": "https://doi.org/10.1016/j.neurot.2026.e01092",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "lcc",
      "RC346-429"
    ],
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7223229814",
  "pdf_url": "https://www.neurotherapeuticsjournal.org/article/S1878-7479(26)00262-X/pdf",
  "pmcid": "PMC13718405",
  "pmid": "42913321",
  "published": "2026-10-22",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/dzk5rmp20x5m0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:35Z",
      "native_id": "a3f4b683283e43cab0e4f8728f539339",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.neurot.2026.e01092"
    },
    {
      "first_seen": "2026-11-02T12:22:26Z",
      "native_id": "PMC13718405",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.neurot.2026.e01092"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Multi-omics analysis of potential therapeutic targets for Alzheimer’s disease and associated differences in immune cell infiltration",
  "title_text": "Multi-omics analysis of potential therapeutic targets for Alzheimer’s disease and associated differences in immune cell infiltration",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:26Z",
  "url": "https://research.draconitic.com/paper/dzk5rmp20x5m0",
  "venue": "Neurotherapeutics",
  "versions": []
}