{
  "abstract": "Magnetic core/shell nanoparticles (CSNPs) are central to emerging imaging and theranostic concepts, yet translating different magnetic payloads into a common, chemically addressable and functionally expandable architecture remains challenging. SMART RHESIN nanocapsules encapsulate different magnetic nanoparticle (NP) systems within a protective phenolic resin shell and permit structural variation and post-synthetic functionalisation. Here we map the design space of SMART RHESIN phenolic resin hollow nanocapsules across 52 reactions varying monomer choice, CSNP type, loading, co-encapsulation, and polymer additives. The platform incorporates magnetic payloads ranging from lab-synthesised magnetite to commercial iron oxides and cubic NPs, while identifying biogenic magnetosomes as a boundary case for the present synthesis conditions, with the resulting nanocapsule diameter (about 100 to 400 nm) and shell thickness (about 10 to 80 nm) varying systematically with the choice of CSNP system and reaction conditions. Magnetic particle spectroscopy (MPS) indicates reduced viscosity-induced phase shifts for selected representative formulations from this expanded compositional set, phantom MPI demonstrates multi-colour imaging that resolves aqueous and immobilised SR29 signals within a single field of view, and surface carboxylates enable post-synthetic modification, illustrated by ¹⁸F-radiolabelling for PET/CT. These findings establish SMART RHESINs as a versatile nanocapsule platform for integrating magnetic NPs with additional optical, radiochemical and future targeting functionalities.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Engineering, Baden-Württemberg Cooperative State University Karlsruhe Erzbergerstr. 121 76133 Karlsruhe Germany esther.roesch@dhbw-karlsruhe.de.",
    "Institute of Inorganic Chemistry, Karlsruhe Institute of Technology Engesserstraße 15 76131 Karlsruhe Germany.",
    "Bruker BioSpin GmbH & Co. KG, Preclinical Imaging Division Rudolf-Plank-Straße 23 76275 Ettlingen Germany.",
    "Institute of Organic Chemistry, Karlsruhe Institute of Technology Fritz-Haber-Weg 6 76131 Karlsruhe Germany.",
    "Laboratoire Softmat, Université de Toulouse, CNRS UMR 5623, Université Toulouse III - Paul Sabatier 118 Route de Narbonne 31062 Toulouse France.",
    "Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST Campus UAB, Bellaterra 08193 Barcelona Spain.",
    "Department of Microbiology, University of Bayreuth Universitätsstraße 30 95447 Bayreuth Germany.",
    "Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tübingen Röntgenweg 15 72076 Tübingen Germany.",
    "Cluster of Excellence iFIT (EXC 2180) \"Image-Guided and Functionally Instructed Tumour Therapies\", Eberhard Karls University Tübingen 72076 Tübingen Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Julia Feye",
      "orcid": "0009-0001-0748-1420"
    },
    {
      "affs": [
        1
      ],
      "name": "David Rudolph",
      "orcid": "0009-0001-1005-7620"
    },
    {
      "affs": [
        1
      ],
      "name": "Jens Treptow"
    },
    {
      "affs": [
        3
      ],
      "name": "Eileen List"
    },
    {
      "affs": [
        4
      ],
      "name": "Luan Passini",
      "orcid": "0000-0002-4866-2455"
    },
    {
      "affs": [
        5
      ],
      "name": "Aritz Lafuente",
      "orcid": "0000-0002-1497-5744"
    },
    {
      "affs": [
        6
      ],
      "name": "Frank Mickoleit",
      "orcid": "0000-0002-1943-3960"
    },
    {
      "affs": [
        6
      ],
      "name": "Sophia Tessaro"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Andreas Maurer",
      "orcid": "0000-0003-2412-5361"
    },
    {
      "affs": [
        2
      ],
      "name": "Serhat Ilbey",
      "orcid": "0000-0002-3574-4320"
    },
    {
      "affs": [
        2
      ],
      "name": "Jochen Franke",
      "orcid": "0000-0002-0592-3010"
    },
    {
      "affs": [
        6
      ],
      "name": "René Uebe",
      "orcid": "0000-0003-2357-1589"
    },
    {
      "affs": [
        6
      ],
      "name": "Dirk Schüler",
      "orcid": "0000-0002-2327-0762"
    },
    {
      "affs": [
        5
      ],
      "name": "Alejandro G Roca",
      "orcid": "0000-0001-6610-9197"
    },
    {
      "affs": [
        4
      ],
      "name": "Clément Roux",
      "orcid": "0000-0001-5707-4471"
    },
    {
      "affs": [
        3
      ],
      "name": "Hans-Achim Wagenknecht",
      "orcid": "0000-0003-4849-2887"
    },
    {
      "affs": [
        1
      ],
      "name": "Claus Feldmann",
      "orcid": "0000-0003-2426-9461"
    },
    {
      "affs": [
        1
      ],
      "name": "Peter W Roesky",
      "orcid": "0000-0002-0915-3893"
    },
    {
      "affs": [
        0
      ],
      "name": "Esther S Rösch",
      "orcid": "0000-0002-9996-8390"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dztpnxwt3nmx9.bib",
  "cited_by": 0,
  "doi": "10.1039/d6tc02161a",
  "fulltext_url": "https://europepmc.org/articles/PMC13679676",
  "id": "dztpnxwt3nmx9",
  "issns": [
    "2050-7526",
    "2050-7534"
  ],
  "landing_url": "https://europepmc.org/article/MED/42899239",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
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      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
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  "openalex": "W7222984529",
  "pdf_url": null,
  "pmcid": "PMC13679676",
  "pmid": "42899239",
  "published": "2026-10-19",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/dztpnxwt3nmx9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42899239",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42899239"
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    {
      "first_seen": "2026-11-02T12:20:44Z",
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      "url": "https://hal.science/hal-05847773v1"
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Exploring the design space of SMART RHESINs as a modular nanocapsule platform for functional magnetic nanoparticles.",
  "title_text": "Exploring the design space of SMART RHESINs as a modular nanocapsule platform for functional magnetic nanoparticles.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:20:47Z",
  "url": "https://research.draconitic.com/paper/dztpnxwt3nmx9",
  "venue": "Journal of materials chemistry. C",
  "versions": []
}