{
  "abstract": "Nucleotide-binding domain and leucine-rich repeat-containing proteins (NLRs) are central mediators of inflammasome signaling, activating caspase-1 to drive pyroptotic cell death and pro-inflammatory responses. Although NLR activation is generally thought to involve conformational rearrangements that oligomerize their N- or C-terminal death domains to nucleate ASC or pro-caspase-1 oligomerization, the molecular mechanisms that enable these transitions vary substantially among family members. Here, we highlight recent structural advances that reveal how distinct NLRs are activated and assemble into higher-order signaling platforms, providing mechanistic insights into the diverse activation mechanisms that converge on a common inflammatory outcome.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Yichao Liu"
    },
    {
      "name": "Kexin Ji"
    },
    {
      "name": "Liman Zhang",
      "orcid": "0000-0002-7247-7655"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dzy4gdjqambsk.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11169-w",
  "fulltext_url": "https://europepmc.org/articles/PMC13680356",
  "id": "dzy4gdjqambsk",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11169-w",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "openalex",
      "1312|Inflammasome and immune disorders"
    ]
  ],
  "openalex": "W7222975256",
  "pdf_url": "https://www.nature.com/articles/s42003-026-11169-w.pdf",
  "pmcid": "PMC13680356",
  "pmid": "42897236",
  "published": "2026-10-19",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/dzy4gdjqambsk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "10.1038/s42003-026-11169-w",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11169-w"
    },
    {
      "first_seen": "2026-10-30T12:19:33Z",
      "native_id": "MED:42897236",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897236"
    },
    {
      "first_seen": "2026-10-30T13:46:19Z",
      "native_id": "24ed67b528a543eea25eaef6f2d18027",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s42003-026-11169-w"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Inflammasome and immune disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Molecular mechanisms of NLR proteins in inflammasome activation",
  "title_text": "Molecular mechanisms of NLR proteins in inflammasome activation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:19Z",
  "url": "https://research.draconitic.com/paper/dzy4gdjqambsk",
  "venue": "Communications Biology",
  "versions": []
}