{
  "abstract": "Nuclear Envelope Membrane Protein 1 (NEMP1) is highly expressed in oocytes and required for fertility, yet its meiotic function remains poorly understood. Here, we identify NEMP1 as a critical organizer of meiotic telomere-nuclear envelope coupling and chromosome dynamics. Loss of NEMP1 causes telomere aggregation, loss of shelterin protection, telomere shortening, persistent DNA damage, aberrant non-homologous end joining, and chromosome end-to-end fusion, ultimately leading to aneuploidy in mouse oocyte. NEMP1 is required during early fetal meiotic prophase I for telomere-nuclear envelope attachment, bouquet formation, homolog pairing, and synapsis. Live cell imaging revealed robust rapid prophase movements in wild-type meiocytes, which were nearly abolished by NEMP1 loss and restored by NEMP1-GFP re-expression. Mechanistically, NEMP1 associates with telomeric DNA and the SUN1-KASH5 LINC machinery, and SUN1-GFP restores chromosome movement in Nemp1-deficient meiocytes. Together, these findings establish NEMP1 as a nuclear-envelope organizer linking telomere protection, chromosome dynamics, and genome integrity during mammalian oogenesis.",
  "abstract_shown": true,
  "affiliations": [
    "Washington University School of Medicine"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "H. Zhang"
    },
    {
      "name": "L. Zhang"
    },
    {
      "name": "S. Pangas"
    },
    {
      "name": "A. Jurisicova"
    },
    {
      "affs": [
        0
      ],
      "name": "H. McNeill"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/dzyah02pdfyez.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.17.752236",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.17.752236v1.full",
  "id": "dzyah02pdfyez",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.17.752236v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "developmental biology"
    ],
    [
      "openalex",
      "1312|Nuclear Structure and Function"
    ]
  ],
  "openalex": "W7213553267",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.17.752236v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-17",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/dzyah02pdfyez.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:23:04Z",
      "native_id": "10.64898/2026.09.17.752236",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.17.752236v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:developmental biology",
      "subfield": "developmental-biology"
    }
  ],
  "title": "NEMP1 organizes the meiotic telomere LINC interface to control chromosome movement and telomere integrity",
  "title_text": "NEMP1 organizes the meiotic telomere LINC interface to control chromosome movement and telomere integrity",
  "type": "preprint",
  "updated_at": "2026-10-30T12:23:04Z",
  "url": "https://research.draconitic.com/paper/dzyah02pdfyez",
  "venue": "bioRxiv",
  "versions": []
}