{
  "abstract": "Objective\n\nThis study aimed to evaluate nintedanib's therapeutic effects on mice silicosis by examining pulmonary function, lung inflammation, and fibrosis.Methods\n\nMice were categorized into preventive and therapeutic groups, each with control, low-dose, and high-dose treatment subgroups. Cell counts in bronchoalveolar lavage fluid and cytokines in the lung tissue were detected using quantitative polymerase chain reaction. The right ventricular hypertrophy index (RVHI) was assessed, and lung collagen deposition and inflammation were analyzed using various histological and molecular techniques. Forced lung function tests were conducted to evaluate lung compliance, total lung capacity (TLC), and the mouse airway resistance.Results\n\nIn the preventive group, neutrophil counts and levels of pro-inflammatory cytokines in lung tissue were significantly lower in the treatment group than in the control group, with no significant differences in the RVHI. Collagen deposition and pathological scores for inflammation and fibrosis were reduced in the treatment group. In lung function tests, TLC was higher and resistance lower in the high-dose group. In the therapeutic group, cytokine levels and the RVHI were significantly lower in the treatment group, while collagen type I mRNA expression was statistically significant. Lung function tests revealed improved TLC and resistance in the treatment group.Conclusion\n\nNintedanib reduces lung inflammation, fibrosis, and right ventricular hypertrophy in mice with silicosis, demonstrating potential therapeutic effects.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pneumoconiosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Yangpu District, Shanghai, 200433, China.",
    "2nd People's Hospital of Shanxi Province, 9 West Kouzhuang Rd., Taiyuan, Shanxi Province, 030012, China.",
    "Department of Central Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, 507 Zhengmin Rd., Shanghai, 200433, China.",
    "Department of Respiratory and Pneumoconiosis, 2nd People's Hospital of Shanxi Province, 9 West Kouzhuang Rd., Taiyuan, Shanxi Province, 030012, China. 1643745687@qq.com.",
    "Department of Pneumoconiosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Yangpu District, Shanghai, 200433, China. maoling113@sina.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Limin Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Li Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Liang Tang"
    },
    {
      "affs": [
        3
      ],
      "name": "Hongxia Tian"
    },
    {
      "affs": [
        4
      ],
      "name": "Ling Mao",
      "orcid": "0000-0003-3909-8765"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e04snkb54shjt.bib",
  "cited_by": 0,
  "doi": "10.1186/s12890-026-04546-y",
  "fulltext_url": "https://europepmc.org/articles/PMC13688955",
  "id": "e04snkb54shjt",
  "issns": [
    "1471-2466"
  ],
  "landing_url": "https://europepmc.org/article/MED/42907787",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC705-779"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://europepmc.org/articles/PMC13688955?pdf=render",
  "pmcid": "PMC13688955",
  "pmid": "42907787",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/e04snkb54shjt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42907787",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42907787"
    },
    {
      "first_seen": "2026-10-30T13:45:32Z",
      "native_id": "0ac5d28429fc459c872b7634de7f38f1",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12890-026-04546-y"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC705-779",
      "subfield": "general"
    }
  ],
  "title": "Nintedanib alleviates pulmonary inflammation and fibrosis in mice with silicosis.",
  "title_text": "Nintedanib alleviates pulmonary inflammation and fibrosis in mice with silicosis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:20:39Z",
  "url": "https://research.draconitic.com/paper/e04snkb54shjt",
  "venue": "BMC pulmonary medicine",
  "versions": []
}