{
  "abstract": "Targeting soluble neurosensitizers in the osteoarthritis (OA) joint cavity is a key strategy for alleviating OA pain. Soluble neurosensitizers are ubiquitous in the joint cavity and cause uncontrollable growth and sensitization of nociceptor axons therein. However, eliminating these soluble nerve growth factors (NGFs) remains a considerable challenge due to the diversity of neurosensitizers and the complexity of OA pathology. This study introduces an innovative soluble nanodrug (LAC)‐based strategy to eliminate three key neurosensitizers (H+, NGF, and netrin‐1) to simultaneously relieve OA‐associated pain and joint damage. In two animal model experiments, LAC significantly reduced pain and alleviated OA progression by reducing synovial inflammation and inhibiting cartilage and subchondral bone damage. This strategy of using soluble nanomedicine to counter soluble neurosensitizers not only provides inspiration for eliminating pain, but also sheds light on possible solutions for advancing OA treatment strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopaedics The Third Xiangya Hospital Central South University Changsha China",
    "Department of Orthopaedics Xiangya Hospital Central South University Changsha China",
    "Xiangya School of Pharmaceutical Sciences Central South University Changsha China",
    "Department of Pharmacology and Chemical Biology College of Basic Medical Sciences Shanghai Jiao Tong University School of Medicine Shanghai China",
    "Department of Pharmacy Xiangya Hospital Central South University Changsha China",
    "Key Laboratory of Aging‐Related Bone and Joint Diseases Prevention and Treatment Ministry of Education Xiangya Hospital Central South University Changsha China",
    "Department of Endocrinology Endocrinology Research Center Xiangya Hospital of Central South University Changsha China",
    "Hunan Key Laboratory of Joint Degeneration and Injury Changsha China",
    "National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Junyan Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Feixiang Ding"
    },
    {
      "affs": [
        3
      ],
      "name": "Jiayi Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Min Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Lingyu Su"
    },
    {
      "affs": [
        2
      ],
      "name": "Zixi Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Congying Pi"
    },
    {
      "affs": [
        4
      ],
      "name": "Shilong Jiang"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhaokui Zeng"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Changjun Li"
    },
    {
      "affs": [
        1,
        5,
        7,
        8
      ],
      "name": "Chao Zeng"
    },
    {
      "affs": [
        1,
        5,
        7,
        8
      ],
      "name": "Guanghua Lei"
    },
    {
      "affs": [
        2
      ],
      "name": "Kelong Ai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e0660wrr3qhgy.bib",
  "cited_by": 0,
  "doi": "10.1002/exp2.70233",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13650196/",
  "id": "e0660wrr3qhgy",
  "issns": [
    "2766-8509",
    "2766-2098"
  ],
  "landing_url": "https://doi.org/10.1002/exp2.70233",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2745|Osteoarthritis Treatment and Mechanisms"
    ]
  ],
  "openalex": "W7221088982",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/exp2.70233",
  "pmcid": "PMC13650196",
  "pmid": "42857293",
  "published": "2026-10-08",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/e0660wrr3qhgy.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:23:35Z",
      "native_id": "PMC13650196",
      "source": "pmc",
      "url": "https://doi.org/10.1002/exp2.70233"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Osteoarthritis Treatment and Mechanisms",
      "subfield": "general"
    }
  ],
  "title": "Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage",
  "title_text": "Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:15Z",
  "url": "https://research.draconitic.com/paper/e0660wrr3qhgy",
  "venue": "Exploration",
  "versions": []
}