{
  "abstract": "Physical activity improves metabolic health, but the molecular responses that mediate its benefits are not fully characterized. Here we present a high-resolution, time-resolved proteomics atlas across plasma, saliva and urine from 25 healthy men in response to acute exercise. We find that exercise regulates more than 3,000 proteins through distinct, fluid-specific temporal dynamics. Network analysis uncovers coordinated remodelling of protein secretion, extracellular matrix and immune activation across body fluids. Replication in an independent cohort shows that many exercise-responsive plasma proteins exhibit consistent responses across age, sex and exercise modalities. Integration with human genome-wide association study data links secreted, exercise-responsive proteins to cardiometabolic diseases. Functional validation of genetically prioritized muscle-specific secreted proteins in Drosophila confirms their role in endurance, behaviour and metabolism. Overall, this open-access atlas ( https://cbmr.ku.dk/research/research-groups/deshmukh-group/shiny-apps/ ) provides a multifluid resource that complements existing exercise-omics efforts for defining molecular adaptations to exercise and for prioritizing candidate exerkines.",
  "abstract_shown": true,
  "affiliations": [
    "Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. nigel.kurgan@sund.ku.dk.",
    "Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.",
    "Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.",
    "Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.",
    "Global translation, Måløv, Denmark.",
    "Department of Biology, University of Copenhagen, Copenhagen, Denmark.",
    "The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.",
    "Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. bente.klarlund.pedersen@regionh.dk.",
    "Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. atul.deshmukh@sund.ku.dk."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nigel Kurgan",
      "orcid": "0000-0002-5011-0297"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Jeppe Kjærgaard",
      "orcid": "0000-0002-9304-1148"
    },
    {
      "affs": [
        3
      ],
      "name": "Naja Zenius Jespersen",
      "orcid": "0000-0002-3488-1657"
    },
    {
      "affs": [
        1
      ],
      "name": "Virginia Díez-Obrero",
      "orcid": "0000-0002-0163-9872"
    },
    {
      "affs": [
        1
      ],
      "name": "Victor Svenstrup"
    },
    {
      "affs": [
        1
      ],
      "name": "Roger Moreno-Justicia",
      "orcid": "0000-0002-8587-4772"
    },
    {
      "affs": [
        3
      ],
      "name": "Sarah Elizabeth Heywood"
    },
    {
      "affs": [
        1
      ],
      "name": "Cecilie Bergmann Lindqvist"
    },
    {
      "affs": [
        1
      ],
      "name": "Lisa Ottander"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Diana Samodova-Sommer"
    },
    {
      "affs": [
        5
      ],
      "name": "Alina Malita"
    },
    {
      "affs": [
        5
      ],
      "name": "Olga Kubrak",
      "orcid": "0009-0008-2540-6628"
    },
    {
      "affs": [
        5
      ],
      "name": "Nadja Ahrentløv",
      "orcid": "0000-0002-2158-3968"
    },
    {
      "affs": [
        3
      ],
      "name": "Nina Sloth Nielsen",
      "orcid": "0000-0001-6564-4278"
    },
    {
      "affs": [
        3
      ],
      "name": "Cody Garett Durrer"
    },
    {
      "affs": [
        5
      ],
      "name": "Michael Texada",
      "orcid": "0000-0003-2479-1241"
    },
    {
      "affs": [
        3
      ],
      "name": "Mathias Ried-Larsen",
      "orcid": "0000-0002-8388-5291"
    },
    {
      "affs": [
        1
      ],
      "name": "Simon Rasmussen",
      "orcid": "0000-0001-6323-9041"
    },
    {
      "affs": [
        5
      ],
      "name": "Kim Rewitz",
      "orcid": "0000-0002-4409-9941"
    },
    {
      "affs": [
        1,
        6
      ],
      "name": "Ruth J F Loos",
      "orcid": "0000-0002-8532-5087"
    },
    {
      "affs": [
        1,
        6
      ],
      "name": "Roelof Adriaan Johan Smit"
    },
    {
      "affs": [
        7
      ],
      "name": "Bente Klarlund Pedersen",
      "orcid": "0000-0001-6508-6288"
    },
    {
      "affs": [
        8
      ],
      "name": "Atul Shahaji Deshmukh",
      "orcid": "0000-0002-2278-1843"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e09fcpz0gwr8j.bib",
  "cited_by": 0,
  "doi": "10.1038/s42255-026-01621-w",
  "fulltext_url": "https://europepmc.org/articles/PMC13690580",
  "id": "e09fcpz0gwr8j",
  "issns": [
    "2522-5812"
  ],
  "landing_url": "https://europepmc.org/article/MED/42864437",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Exercise and Physiological Responses"
    ]
  ],
  "openalex": "W7221548914",
  "pdf_url": "https://europepmc.org/articles/PMC13690580?pdf=render",
  "pmcid": "PMC13690580",
  "pmid": "42864437",
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e09fcpz0gwr8j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42864437",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42864437"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Exercise and Physiological Responses",
      "subfield": "general"
    }
  ],
  "title": "Systemic proteomic dynamics of acute exercise reveal genetic links to health and disease.",
  "title_text": "Systemic proteomic dynamics of acute exercise reveal genetic links to health and disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/e09fcpz0gwr8j",
  "venue": "Nature metabolism",
  "versions": []
}