{
  "abstract": "Objective: To evaluate the efficacy and safety of three oliceridine different doses for oliceridine for patient-controlled analgesia (PCIA) in patients undergoing during total laparoscopic hysterectomy, following the premature termination of the planned sufentanil control arm. Methods: This prospective, randomized, double-blind trial was originally designed as a four-arm study. Due to operational challenges in patient recruitment and randomization within the single-center setting-specifically, significant reluctance among eligible patients to be randomized to receive a traditional opioid regimen when oliceridine was available, leading to unsustainable enrollment timelines—the sufentanil control arm was prematurely terminated. The final analysis therefore focused on three oliceridine doses: 0.1, 0.35, and 0.5 mg/kg, diluted to 100 ml with normal saline for 48-hour PCIA. The primary endpoint for sample size calculation was the incidence of postoperative nausea and vomiting (PONV) at 24 h. Efficacy and safety outcomes analyzed included: NRS pain scores (at rest and during cough), Ramsay sedation scores, incidence of rescue analgesia, various recovery indicators (time to first flatus, time to ambulation, QoR-15 scores), and opioid-related adverse events. Results: Compared to the low-dose group, the moderate- and high-dose groups demonstrated significant improvements in cough-pain scores and bolus press attempts (“Bolus press attempts” were defined as the total number of patient-initiated demands for a supplemental dose, including attempts made within the lockout interval) (p < 0.0083). Further comparison revealed that the moderate-dose group showed the best recovery outcomes, including shorter time to first flatus and ambulation, and higher QoR-15 scores. In contrast, although the high-dose group provided more potent analgesia, it was associated with a higher incidence of nausea, delayed flatus, and a significantly lower quality of recovery (QoR-15) score at 48 hours postoperatively compared to the moderate-dose group (p < 0.0083). Conclusion: Within the investigated PCA oliceridine dose range, the 0.35 mg/kg dose promotes early recovery in patients undergoing laparoscopic total hysterectomy through effective analgesia and reduced nausea, representing the best balance between efficacy and safety among the tested oliceridine-specific regimens.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, China",
    "Department of Anesthesiology, The Cancer Hospital Affiliated to Chongqing University, Chongqing, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
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        0
      ],
      "name": "Jiaojiao Deng"
    },
    {
      "affs": [
        1
      ],
      "name": "Baobao Ma"
    },
    {
      "name": "Kaihua Wei"
    },
    {
      "name": "Tao Wei"
    },
    {
      "name": "Liping Xie"
    },
    {
      "name": "Hong Zhang"
    },
    {
      "name": "Changxu Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e0af9txe4waz6.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0357372",
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  "id": "e0af9txe4waz6",
  "issns": [
    "1932-6203"
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  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2703|Pain Management and Opioid Use"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Nausea"
    ],
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      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Pain"
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      "plos",
      "/Medicine and health sciences/Pain management/Analgesics"
    ],
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      "/Medicine and health sciences/Pharmaceutics/Drug therapy/Analgesia"
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      "/Medicine and health sciences/Pharmacology/Drugs/Analgesics"
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      "/Medicine and health sciences/Pharmacology/Sedation"
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      "/Medicine and health sciences/Surgical and invasive medical procedures"
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      "/Medicine and health sciences/Surgical and invasive medical procedures/Laparoscopy"
    ],
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      "plos",
      "/Medicine and health sciences/Surgical and invasive medical procedures/Reproductive system procedures/Hysterectomy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Surgical and invasive medical procedures/Surgical excision/Hysterectomy"
    ]
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  "openalex": "W7207776510",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0357372&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-03",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/e0af9txe4waz6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "10.1371/journal.pone.0357372",
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      "url": "https://doi.org/10.1371/journal.pone.0357372"
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  "subjects": [
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      "subfield": "pharmacology-toxicology"
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    {
      "field": "medicine",
      "origin": "plos:surgical and invasive medical procedures",
      "subfield": "surgery"
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  ],
  "title": "Efficacy of different doses of oliceridine for Patient-Controlled Intravenous Analgesia in patients undergoing Total Laparoscopic Hysterectomy",
  "title_text": "Efficacy of different doses of oliceridine for Patient-Controlled Intravenous Analgesia in patients undergoing Total Laparoscopic Hysterectomy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/e0af9txe4waz6",
  "venue": "PLOS One",
  "versions": []
}