{
  "abstract": "The fetus acquires a graft of maternal cells in utero, known as maternal microchimerism (MMc), which may be enriched for T cells. However, little is known regarding the determinants of T cell trafficking into the fetus or regarding the prevalence of T cell MMc in healthy neonates. Using a closely followed cohort, we determined the association between maternal vaccination and acute infection and the detection of T cell MMc in cord blood, as measured using polymorphism-specific qPCR. We identified an association between early pregnancy SARS2 mRNA vaccination, a potent T cell stimulus, and increased detection of T cell MMc.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, WA",
    "Institute for Public Health Genetics, University of Washington School of Public Health, Seattle, WA",
    "Department of Obstetrics & Gynecology, University of Washington School of Medicine, Seattle, WA",
    "Department of Pediatrics, University of Washington School of Medicine, Seattle, WA",
    "Department of Global Health, University of Washington, Seattle, WA"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jacquelyn Weaver"
    },
    {
      "affs": [
        0
      ],
      "name": "John Houck"
    },
    {
      "affs": [
        0
      ],
      "name": "Yonghou Jiang"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Cara Tobey"
    },
    {
      "affs": [
        2
      ],
      "name": "Jia Wong"
    },
    {
      "affs": [
        2
      ],
      "name": "Swati Shree"
    },
    {
      "affs": [
        0,
        3,
        4
      ],
      "name": "Whitney E Harrington",
      "orcid": "0000-0002-0121-978X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e0p55nmqkysjj.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.23.761412",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.23.761412v1.full",
  "id": "e0p55nmqkysjj",
  "issns": [
    "2692-8205"
  ],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.23.761412v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "immunology"
    ],
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2403|Reproductive System and Pregnancy"
    ]
  ],
  "openalex": "W7224108779",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.23.761412v1.full.pdf",
  "pmcid": "PMC13733817",
  "pmid": "42990256",
  "published": "2026-10-23",
  "publisher": "Cold Spring Harbor Laboratory Preprints",
  "ris": "https://research.draconitic.com/paper/e0p55nmqkysjj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:30:16Z",
      "native_id": "10.64898/2026.10.23.761412",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.23.761412v1"
    },
    {
      "first_seen": "2026-11-08T12:23:31Z",
      "native_id": "PMC13733817",
      "source": "pmc",
      "url": "https://doi.org/10.64898/2026.10.23.761412"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Neonatal T cell maternal microchimerism is common and associates with early pregnancy SARS2 vaccination",
  "title_text": "Neonatal T cell maternal microchimerism is common and associates with early pregnancy SARS2 vaccination",
  "type": "preprint",
  "updated_at": "2026-11-08T12:23:31Z",
  "url": "https://research.draconitic.com/paper/e0p55nmqkysjj",
  "venue": "bioRxiv",
  "versions": []
}