{
  "abstract": "Strong optical scattering limits the depth at which light can be focused and used for imaging in biological tissue. Photoacoustic (PA)-guided wavefront shaping enables non-invasive light focusing in scattering media, but most existing implementations require optical and acoustic access from opposite sides of the sample and a rigidly aligned free-space optical path, which have confined these demonstrations to thin or static samples. Here, we combine a real-valued intensity transmission matrix (RVITM) algorithm with a photoacoustic guidestar (PA-RVITM) in a reflection-mode configuration. Modulated light is delivered through a flexible multimode fiber passing through the central aperture of a focused ultrasound transducer, enabling optical illumination and acoustic detection from the same side of the sample without a free-space combiner. Fiber integration preserved the wavefront shaping performance, and the reflection-mode PA-RVITM system achieved sub-second wavefront optimization with a ~14-fold PA signal enhancement through a diffuser. In ex vivo chicken breast tissue, the enhancement decreased with tissue thickness, reaching ~3.5 through a 2-mm chicken breast layer, with a speckle decorrelation time of ~450 ms. By performing an independent RVITM optimization at each scan position, our system enabled photoacoustic microscopy of a black nylon wire through the same layer, reducing the imaged line width from ~141 μm to ~102 μm, close to the nominal diameter of ~100 μm. This work advances PA-guided wavefront shaping toward a compact, same-side implementation for future biomedical therapeutic and imaging applications.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2610.20237",
  "author_total": 5,
  "authors": [
    {
      "name": "Xuan Liu"
    },
    {
      "name": "Sacha Noimark"
    },
    {
      "name": "Wenfeng Xia"
    },
    {
      "name": "Sebastien Ourselin"
    },
    {
      "name": "Tianrui Zhao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e0tkfgv49mdn7.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2610.20237",
  "fulltext_url": null,
  "id": "e0tkfgv49mdn7",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2610.20237",
  "language": null,
  "licence": "LicenseRef-arXiv-nonexclusive-1.0",
  "licence_label": "arXiv licence",
  "licence_source": "article",
  "licence_url": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "physics.optics"
    ],
    [
      "openalex",
      "3102|Random lasers and scattering media"
    ]
  ],
  "openalex": "W7222049740",
  "pdf_url": "https://arxiv.org/pdf/2610.20237",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e0tkfgv49mdn7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:29:31Z",
      "native_id": "2610.20237",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2610.20237"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "arxiv:physics.optics",
      "subfield": "optics-photonics"
    }
  ],
  "title": "Photoacoustic-guided reflection-mode wavefront shaping through dynamic biological tissue",
  "title_text": "Photoacoustic-guided reflection-mode wavefront shaping through dynamic biological tissue",
  "type": "preprint",
  "updated_at": "2026-10-30T12:29:31Z",
  "url": "https://research.draconitic.com/paper/e0tkfgv49mdn7",
  "venue": "arXiv",
  "versions": []
}