{
  "abstract": "IntroductionLong non-coding RNAs (lncRNAs) play critical regulatory roles in the pathogenesis of cervical cancer, and accurate identification of lncRNA–cervical cancer associations is important for understanding the molecular mechanisms of the disease and discovering potential therapeutic targets. However, the extreme scarcity of cervical cancer-specific lncRNA association data constitutes a major bottleneck limiting the performance of existing computational prediction methods.MethodsTo address this challenge, we propose a Multi-View Collaborative Variational Autoencoder based on Knowledge Distillation Transfer Learning (MVCVAE), which integrates multi-source heterogeneous data fusion and cross-disease knowledge transfer in a task-oriented manner. The multi-view collaborative variational autoencoder constructs dual-view feature representations of lncRNA and disease similarities and employs a symmetric encoder–decoder architecture to learn complex lncRNA–disease association patterns in the latent space. The knowledge distillation transfer learning framework adopts a teacher–student network design: a teacher model is pre-trained on a large-scale dataset containing 12,865 lncRNA–disease associations to learn general association patterns, and the resulting prior knowledge is effectively transferred to a student model targeting 92 cervical cancer associations through feature distillation and prediction distillation strategies.ResultsIn five-fold cross-validation, MVCVAE achieves an AUC of 0.9228 ± 0.0058.DiscussionThrough the synergistic effects of multi-view heterogeneous information fusion and cross-domain knowledge transfer, MVCVAE demonstrates strong performance in predicting lncRNA–cervical cancer associations, effectively addressing the limitations imposed by the scarcity of cervical cancer-specific lncRNA association data.",
  "abstract_shown": true,
  "affiliations": [
    "Xinjiang Medical University Cancer Hospital, Urumqi, Xinjiang, China",
    "Kecheng District People’s Hospital, Quzhou, Zhejiang, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Min Yuan"
    },
    {
      "affs": [
        0
      ],
      "name": "Tingchuan Xiong"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiariwana Abasi"
    },
    {
      "affs": [
        0
      ],
      "name": "Runmei Guo"
    },
    {
      "affs": [
        1
      ],
      "name": "Yandan Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Guzhalinuer Abulizi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e0vccchc62vpw.bib",
  "cited_by": 0,
  "doi": "10.3389/fgene.2026.1937699",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fgene.2026.1937699/full",
  "id": "e0vccchc62vpw",
  "issns": [
    "1664-8021"
  ],
  "landing_url": "https://doi.org/10.3389/fgene.2026.1937699",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH426-470"
    ],
    [
      "openalex",
      "1306|Cancer-related molecular mechanisms research"
    ]
  ],
  "openalex": "W4417413382",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/e0vccchc62vpw.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T14:21:15Z",
      "native_id": "231b537750c94aae9d878074ddfdd154",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fgene.2026.1937699"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer-related molecular mechanisms research",
      "subfield": "oncology"
    }
  ],
  "title": "Prediction of lncRNA–cervical cancer associations using a multi-view collaborative variational autoencoder with knowledge distillation transfer learning",
  "title_text": "Prediction of lncRNA–cervical cancer associations using a multi-view collaborative variational autoencoder with knowledge distillation transfer learning",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T14:20:44Z",
  "url": "https://research.draconitic.com/paper/e0vccchc62vpw",
  "venue": "Frontiers in Genetics",
  "versions": []
}