{
  "abstract": "Obesity contributes to increased morbidity and mortality, yet its metabolic heterogeneity remains underexplored in sub-Saharan Africa. This study examined associations between body composition, insulin sensitivity, inflammation, and the metabolically healthy profile (MHP), and assessed cardiovascular risk among Cameroonian adults with and without obesity. In this cross-sectional study, 490 participants from the West region of Cameroon underwent anthropometric and metabolic assessments. Ten-year cardiovascular risk was estimated using the Framingham risk score. Logistic regression identified predictors of MHP and determinants of elevated cardiovascular risk. The prevalence of MHP was 59.6% among individuals with normal weight, 11.5% among those with overweight, and 38.2% among those with obesity. Participants with overweight, obesity, android obesity or insulin resistance were 92%, 59%, 58%, and 46% less likely to have a MHP than participants in the control groups, respectively. Inflammation defined solely by CRP-hs was not predictive. Compared with metabolically unhealthy counterparts, metabolically healthy obese (OR = 6.27; 95% CI: 3.15-12.48) and overweight (OR = 2.50; 95% CI: 0.72-8.65) individuals had substantially lower predicted 10-year cardiovascular risk. Metabolic phenotyping reveals that not all Cameroonians with overweight and obesity present the same cardiovascular risk. Incorporating fat distribution and insulin sensitivity into clinical evaluation could improve early identification of high-risk individuals and guide tailored prevention strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Centre for Food, Food Security and Nutrition Research, Institute of Medical Research and Medicinal Plant Studies, Yaounde, Cameroon",
    "Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaoundé, Cameroon",
    "Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, Cameroon",
    "Department of Biotechnology and Food Technology, University of Johannesburg, Johannesburg, South Africa"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Maxwell Wandji Nguedjo"
    },
    {
      "affs": [
        1
      ],
      "name": "Ousmane Mfopou Mbiondi"
    },
    {
      "affs": [
        2
      ],
      "name": "Kevin Fabrice Paul Mandeng"
    },
    {
      "affs": [
        3
      ],
      "name": "Alex Dimitri Tchuenchieu Kamgain"
    },
    {
      "name": "Gabriel Nama Medoua"
    },
    {
      "name": "Judith Laure Ngondi"
    },
    {
      "name": "Julius Enyong Oben"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e0vvbeq34e8mv.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pgph.0006870",
  "fulltext_url": "https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0006870",
  "id": "e0vvbeq34e8mv",
  "issns": [
    "2767-3375"
  ],
  "landing_url": "https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0006870",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2712|Diabetes, Cardiovascular Risks, and Lipoproteins"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Hormones/Insulin"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Metabolism/Carbohydrate metabolism/Glucose metabolism"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Metabolism/Protein metabolism"
    ],
    [
      "plos",
      "/Biology and life sciences/Immunology/Immune response/Inflammation"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Physiological parameters/Body weight/Obesity"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Physiological parameters/Body weight/Overweight"
    ],
    [
      "plos",
      "/Medicine and health sciences/Cardiology/Cardiovascular medicine/Cardiovascular diseases/Cardiovascular disease risk"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Inflammation"
    ],
    [
      "plos",
      "/Medicine and health sciences/Endocrinology/Diabetic endocrinology/Insulin"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Immune response/Inflammation"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Cardiovascular diseases/Cardiovascular disease risk"
    ],
    [
      "plos",
      "/Medicine and health sciences/Vascular medicine/Blood pressure"
    ]
  ],
  "openalex": "W7214067807",
  "pdf_url": "https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0006870&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-23",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/e0vvbeq34e8mv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "10.1371/journal.pgph.0006870",
      "source": "plos",
      "url": "https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0006870"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "plos:metabolism",
      "subfield": "enzymology-metabolism"
    },
    {
      "field": "biology",
      "origin": "plos:immunology",
      "subfield": "immunology"
    },
    {
      "field": "medicine",
      "origin": "plos:physiology",
      "subfield": "physiology"
    }
  ],
  "title": "Metabolic health and cardiovascular risk among Cameroonian adults with and without obesity",
  "title_text": "Metabolic health and cardiovascular risk among Cameroonian adults with and without obesity",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:43Z",
  "url": "https://research.draconitic.com/paper/e0vvbeq34e8mv",
  "venue": "PLOS Global Public Health",
  "versions": []
}