{
  "abstract": "A substantial body of evidence exists demonstrating that exposure to per- and polyfluoroalkyl substances (PFASs) poses a risk to human health. Data from epidemiological studies of those exposed occupationally or environmentally demonstrate adverse health risks, and these health effects are concordant with data from toxicological studies. Systematic reviews, conducted by agencies, organizations, and independent scientists that synthesize and integrate these data streams, have concluded that a range of health risks arise from PFAS exposure, including different types of cancer, especially kidney and testicular cancer, metabolic alterations such as increased liver enzymes and increased cholesterol, immune dysfunction such as reduced vaccination efficiency, reproductive and developmental outcomes such as low birth weight and reduced duration of breast feeding, and forms of endocrine disruption. Despite this, myths and misinformation surrounding these health risks slow efforts to protect public health from the hazards of PFAS exposure. This work addresses the most predominant of these myths and counters them with accumulated evidence from epidemiological and toxicological studies, demonstrating that exposure to PFASs poses a risk to human health.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Environmental and Molecular Toxicology",
    "Oregon State University",
    "Department of Environmental Science",
    "Stockholm University",
    "Milieu Consulting SPRL",
    "NILU, Tromsø 9296, Norway and Division of Environmental Health",
    "Norwegian Institute of Public Health",
    "Graduate School of Oceanography",
    "University of Rhode Island",
    "National Center for Advancing Translational Sciences",
    "U.S. Public Health Service",
    "Department of Civil & Environmental Engineering and Environmental and Occupational Health",
    "University of Pittsburgh",
    "Institute of Biogeochemistry and Pollutant Dynamics, ETH Zürich",
    "Department of Plant and Environmental Sciences, Section for Environmental Chemistry and Physics",
    "University of Copenhagen",
    "Empa-Swiss Federal Laboratories for Materials Science and Technology, St., St. Gallen, CH 9014, Switzerland",
    "National Centre of Competence in Research (NCCR) Catalysis",
    "University of Southern Denmark, Department of Green Technology & Danish Institute for Advanced Study (DIAS)"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jamie C. DeWitt",
      "orcid": "0000-0002-0440-4059"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Ian T. Cousins",
      "orcid": "0000-0002-7035-8660"
    },
    {
      "affs": [
        4
      ],
      "name": "Gretta Goldenman",
      "orcid": "0000-0001-5119-4843"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Dorte Herzke",
      "orcid": "0000-0001-9620-3053"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Rainer Lohmann",
      "orcid": "0000-0001-8796-3229"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Mark Miller",
      "orcid": "0000-0003-1783-889X"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Carla A. Ng",
      "orcid": "0000-0001-5521-7862"
    },
    {
      "affs": [
        13
      ],
      "name": "Martin Scheringer",
      "orcid": "0000-0002-0809-7826"
    },
    {
      "affs": [
        14,
        15
      ],
      "name": "Xenia Trier",
      "orcid": "0000-0001-6067-8321"
    },
    {
      "affs": [
        16,
        17,
        18
      ],
      "name": "Zhanyun Wang",
      "orcid": "0000-0001-9914-7659"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e0ymk788a1x2h.bib",
  "cited_by": 10,
  "doi": "10.1021/acs.est.6c01037",
  "fulltext_url": null,
  "id": "e0ymk788a1x2h",
  "issns": [
    "0013-936X",
    "1520-5851"
  ],
  "landing_url": "https://doi.org/10.1021/acs.est.6c01037",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2304|Per- and polyfluoroalkyl substances research"
    ]
  ],
  "openalex": "W7161604537",
  "pdf_url": null,
  "pmcid": "PMC13261871",
  "pmid": "42149781",
  "published": "2026-05-18",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/e0ymk788a1x2h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:58Z",
      "native_id": "W7161604537",
      "source": "openalex",
      "url": "https://doi.org/10.1021/acs.est.6c01037"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2304|Per- and polyfluoroalkyl substances research",
      "subfield": "environmental"
    }
  ],
  "title": "PFAS Toxicity: What’s True, What’s Not, and What Really Matters",
  "title_text": "PFAS Toxicity: What’s True, What’s Not, and What Really Matters",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:54Z",
  "url": "https://research.draconitic.com/paper/e0ymk788a1x2h",
  "venue": "Environmental Science & Technology",
  "versions": []
}