{
  "abstract": "Objective\n\nThis exploratory study investigated peripheral blood Prestin levels across different hearing loss subtypes to evaluate its potential as a biomarker for inner ear injury.Methods\n\nPlasma Prestin levels were measured via ELISA in 100 age-matched participants, comprising a healthy control group (HCG, n = 23) and patients with conductive (CHLG, n = 29) and unilateral sudden sensorineural hearing loss (USSNHLG, n = 48). Associations with hearing loss subtypes, initial audiogram configurations, and treatment outcomes were analyzed.Results\n\nOverall, Prestin levels varied significantly across the three groups (P < 0.001). Following Dunn's test with Bonferroni correction, Prestin levels in the USSNHLG were significantly higher than those in the HCG (P = 0.019), whereas levels in the CHLG were significantly lower than those in the HCG (P = 0.014). Within the USSNHLG, no statistically significant differences in Prestin levels were observed among patients with different therapeutic outcomes (P = 0.102).Conclusions\n\nThe present findings confirm that acute inner ear injury (USSNHL) is associated with significantly elevated peripheral blood Prestin levels, whereas persistently reduced acoustic input (CHL) is associated with decreased levels. However, current data do not support baseline Prestin as a prognostic indicator for USSNHL. Future multicenter studies with strict clinical stratification are required to fully establish its clinical utility.",
  "abstract_shown": true,
  "affiliations": [
    "Beijing Tongren Hospital, Capital Medical University, China.",
    "The Second Affiliated Hospital of Nanjing Medical University, China.",
    "Shanghai 9th People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.",
    "Beijing Tongren Hospital, Capital Medical University, China. Electronic address: alinaliyi@163.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xuan Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Dian Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yahan Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhenghan Zhu"
    },
    {
      "affs": [
        2
      ],
      "name": "Lingxiang Hu"
    },
    {
      "affs": [
        3
      ],
      "name": "Yi Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e12sfxeeac8q3.bib",
  "cited_by": 0,
  "doi": "10.1016/j.clinsp.2026.101143",
  "fulltext_url": "https://europepmc.org/articles/PMC13691484",
  "id": "e12sfxeeac8q3",
  "issns": [
    "1807-5932",
    "1980-5322"
  ],
  "landing_url": "https://europepmc.org/article/MED/42880127",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2809|Hearing, Cochlea, Tinnitus, Genetics"
    ]
  ],
  "openalex": "W7222296005",
  "pdf_url": "https://europepmc.org/articles/PMC13691484?pdf=render",
  "pmcid": "PMC13691484",
  "pmid": "42880127",
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e12sfxeeac8q3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42880127",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42880127"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2809|Hearing, Cochlea, Tinnitus, Genetics",
      "subfield": "neuroscience"
    }
  ],
  "title": "Prestin as a potential biomarker in peripheral blood: differential expression across hearing loss subtypes and acute inner ear injury.",
  "title_text": "Prestin as a potential biomarker in peripheral blood: differential expression across hearing loss subtypes and acute inner ear injury.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/e12sfxeeac8q3",
  "venue": "Clinics (Sao Paulo, Brazil)",
  "versions": []
}