{
  "abstract": "Aging is characterized by progressive physiological decline and increased susceptibility to age‐related diseases. Conventional rodent models have contributed significantly to our understanding of aging, yet their translational relevance is limited by substantial evolutionary divergence from humans. Here, we introduce the tree shrew ( Tupaia belangeri chinensis ) as a novel and biologically relevant model organism for aging research. In vitro, we induced cellular senescence in tree shrew fibroblasts through ionizing radiation, doxorubicin treatment, or replicative exhaustion, all of which consistently triggered robust senescent phenotypes and a pronounced senescence‐associated secretory phenotype (SASP), accompanied by upregulation of conserved senescence biomarkers. In vivo, aged tree shrews exhibited progressive physical frailty, metabolic dysfunction, organ fibroplasia, and spontaneous tumorigenesis. Transcriptomic profiling uncovered widespread age‐related alterations across multiple tissues, prominently affecting pathways involved in chronic inflammation, extracellular matrix remodeling, and metabolic dysregulation. Further comparative transcriptomic analyses of liver and spleen tissues confirmed that tree shrews recapitulate conserved human aging transcriptional trajectories and core gene expression patterns, whereas mice displayed markedly divergent aging signatures. Notably, senolytic intervention with dasatinib and quercetin (D + Q) effectively reversed key transcriptional changes and ameliorated selected age‐related pathologies, including hepatic steatosis. Importantly, the D + Q‐induced transcriptomic responses in tree shrews exhibited markedly greater concordance with human aging signatures than did corresponding mouse datasets. Collectively, these findings establish the tree shrew as a translationally relevant aging model that bridges the gap between fundamental discovery and clinical application.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences Kunming Yunnan China",
    "University of Chinese Academy of Sciences Beijing China",
    "National Resource Center for Non‐Human Primates, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) Kunming Institute of Zoology, Chinese Academy of Sciences Kunming Yunnan China",
    "School of Chemical Science and Technology Yunnan University Kunming Yunnan China",
    "Laboratory of Molecular Genetics of Aging and Tumor, Medical School Kunming University of Science and Technology Kunming Yunnan China",
    "Key Laboratory of Biodiversity Information Kunming Institute of Zoology, Chinese Academy of Sciences Kunming Yunnan China",
    "KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Yunnan China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Qiuni Luo"
    },
    {
      "affs": [
        2
      ],
      "name": "Wenxian Xiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Dong",
      "orcid": "0000-0002-8692-7469"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ayesha Nisar"
    },
    {
      "affs": [
        2
      ],
      "name": "Yuhua Ma"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiang Lai"
    },
    {
      "affs": [
        0
      ],
      "name": "Raoxian Bai"
    },
    {
      "affs": [
        0
      ],
      "name": "Meiting Zi"
    },
    {
      "affs": [
        2
      ],
      "name": "Qi Geng"
    },
    {
      "affs": [
        2
      ],
      "name": "Qingyu Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Cheng Zhang",
      "orcid": "0000-0001-9328-0424"
    },
    {
      "affs": [
        2
      ],
      "name": "Qiong Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Naheemat Modupeola Gold",
      "orcid": "0009-0003-3141-7044"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zhen Zhou"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Li Hu",
      "orcid": "0009-0001-2215-9130"
    },
    {
      "affs": [
        0
      ],
      "name": "Ao Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qinghua Zeng"
    },
    {
      "affs": [
        4
      ],
      "name": "Jing Liu"
    },
    {
      "affs": [
        5
      ],
      "name": "Sawar Khan",
      "orcid": "0000-0002-6928-7439"
    },
    {
      "affs": [
        2
      ],
      "name": "Longbao Lv"
    },
    {
      "affs": [
        0,
        1,
        6
      ],
      "name": "Yonghan He",
      "orcid": "0000-0003-4409-4590"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e13fxq84dvh8s.bib",
  "cited_by": 0,
  "doi": "10.1111/acel.70781",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731738/",
  "id": "e13fxq84dvh8s",
  "issns": [
    "1474-9718",
    "1474-9726"
  ],
  "landing_url": "https://doi.org/10.1111/acel.70781",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7225230281",
  "pdf_url": null,
  "pmcid": "PMC13731738",
  "pmid": "42977716",
  "published": "2026-11-03",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/e13fxq84dvh8s.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:52Z",
      "native_id": "PMC13731738",
      "source": "pmc",
      "url": "https://doi.org/10.1111/acel.70781"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "Tree Shrew as an Emerging Model for Aging Research: Characterization of Senescence and Therapeutic Interventions",
  "title_text": "Tree Shrew as an Emerging Model for Aging Research: Characterization of Senescence and Therapeutic Interventions",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:52Z",
  "url": "https://research.draconitic.com/paper/e13fxq84dvh8s",
  "venue": "Aging Cell",
  "versions": []
}