{
  "abstract": "Calcific aortic valve disease (CAVD) leads to aortic stenosis (AS) through inflammation and fibro-calcific remodeling. Although CAVD and atherosclerosis share features, not all patients with AS develop atherosclerotic cardiovascular disease (ASCVD), suggesting mechanistic heterogeneity. This case-control study evaluated inflammatory profiles and valvular remodeling in 128 patients with AS (59.4% with ASCVD) and 105 controls. Immune cell composition and monocyte markers were analyzed by flow cytometry, whereas cytokine production was assessed after peripheral blood mononuclear cell (PBMC) stimulation. Both AS groups had higher interleukin (IL)-6, leukocyte, monocyte, and neutrophil counts than controls, with lower monocyte human leukocyte antigen-DR isotype and higher C-C chemokine receptor (CCR)2 expression. Cytokine responses were also elevated, particularly in AS patients with ASCVD. They also showed higher IL-6 concentrations, higher proportions of classical monocytes, and lower intermediate and non-classical monocytes compared with patients without ASCVD. Overall, AS was associated with a pro-inflammatory monocyte phenotype and function, most prominently in patients with ASCVD. ClinicalTrials.gov ID: NCT04717219.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.",
    "Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.",
    "Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.",
    "Department of IQ Health, Radboud University Medical Center, Nijmegen, The Netherlands.",
    "Acibadem Heart Center, Acibadem International Medical Center, Rotterdam, The Netherlands.",
    "Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Immunology and Metabolism, Life and Medical Sciences Center, University of Bonn, Bonn, Germany.",
    "Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands; Department of Cardiac Surgery, Amsterdam University Medical Center, Amsterdam, The Netherlands.",
    "Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands; Department of Pathology, Amsterdam University Medical Center, Amsterdam, The Netherlands.",
    "Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands; Dutch Network for Cardiovascular Research (WCN), Utrecht, The Netherlands; Department of Cardiology, Northwest Clinics, Alkmaar, The Netherlands.",
    "Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Saloua.ElMessaoudi@radboudumc.nl."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Amber van Broekhoven"
    },
    {
      "affs": [
        1
      ],
      "name": "Eveline P M van Doorn"
    },
    {
      "affs": [
        2
      ],
      "name": "Wieteke Broeders"
    },
    {
      "affs": [
        3
      ],
      "name": "Aysun Cetinyurek-Yavuz"
    },
    {
      "affs": [
        4
      ],
      "name": "Erwin S Zegers"
    },
    {
      "affs": [
        5
      ],
      "name": "Mihai G Netea"
    },
    {
      "affs": [
        6
      ],
      "name": "Alexander B A Vonk"
    },
    {
      "affs": [
        0
      ],
      "name": "Niels van Royen"
    },
    {
      "affs": [
        7
      ],
      "name": "Hans W M Niessen"
    },
    {
      "affs": [
        8
      ],
      "name": "Jan H Cornel"
    },
    {
      "affs": [
        2
      ],
      "name": "Niels P Riksen"
    },
    {
      "affs": [
        9
      ],
      "name": "Saloua El Messaoudi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e19j1znrabj9m.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jacbts.2026.101692",
  "fulltext_url": "https://europepmc.org/articles/PMC13694428",
  "id": "e19j1znrabj9m",
  "issns": [
    "2452-302X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42874162",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W7221805793",
  "pdf_url": "https://europepmc.org/articles/PMC13694428?pdf=render",
  "pmcid": "PMC13694428",
  "pmid": "42874162",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e19j1znrabj9m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42874162",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42874162"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Exploratory Analysis of the Innate Immune System in Aortic Stenosis Patients With and Without ASCVD.",
  "title_text": "Exploratory Analysis of the Innate Immune System in Aortic Stenosis Patients With and Without ASCVD.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/e19j1znrabj9m",
  "venue": "JACC. Basic to translational science",
  "versions": []
}