{
  "abstract": "Background/Objectives: Ocimum tenuiflorum (OT) exhibits diverse therapeutic effects linked to its antioxidant activity. Studies integrating phytochemical variability, functional antioxidant localization, and chemometric evaluation of Pharmacopeia-Relevant Extracts (PREs) remain limited. This study investigated phytochemical variability and antioxidant-associated profiling among PREs of OT from geo-climatic regions and commercial sources. Methods: PREs were investigated through High-Performance Thin-Layer Chromatography (HPTLC) fingerprinting, HPTLC-2,2-diphenyl-1-picrylhydrazyl (DPPH) bioautography, HPTLC quantification, Total Phenolic and Flavonoid Content (TPC and TFC), DPPH-IC50 and Ferric Reducing Antioxidant Power (FRAP) assays, correlation statistics, and chemometric analyses. Results: Rosmarinic acid (RA) and ursolic acid (UA) were detected across all PREs; eugenol was not detected but detected in non-polar extracts. HPTLC-DPPH bioautography exhibited antioxidant-associated localization for RA but not UA. RA concentration, TPC, TFC, DPPH-IC50, and FRAP showed substantial variability among PREs. RA correlated more strongly than TPC with antioxidant endpoints: positively with FRAP and inversely with DPPH-IC50; TFC correlated non-significantly with the dataset. Geo-climatic variability was linked to differences in RA, TPC, IC50, and FRAP, with TFC not reaching significance, and varietal differences remained non-significant. Chemometric analyses demonstrated distinguishable clustering among PREs. Conclusions: This study highlights observational trends in geo-climatic phytochemical variation, identifying RA as a major antioxidant-associated marker under the present conditions.",
  "abstract_shown": true,
  "affiliations": [
    "DAC Regional Research Institute, Kolkata 700035, West Bengal, India",
    "Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India",
    "Centre of Medicinal Plants & Research in Homoeopathy, Ooty 643209, Tamil Nadu, India",
    "Central Council for Research in Homoeopathy, New Delhi 110058, India"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Totan Das",
      "orcid": "0009-0007-7509-1356"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ishita Biswas",
      "orcid": "0009-0006-2769-0859"
    },
    {
      "affs": [
        0
      ],
      "name": "Satyajit Maity",
      "orcid": "0009-0003-1732-1943"
    },
    {
      "affs": [
        0
      ],
      "name": "Sayani Maji"
    },
    {
      "affs": [
        2
      ],
      "name": "K. Karunaidhasan"
    },
    {
      "affs": [
        2
      ],
      "name": "V. Anusuba"
    },
    {
      "affs": [
        3
      ],
      "name": "Digvijay Verma"
    },
    {
      "affs": [
        0
      ],
      "name": "Gurudev Choubey"
    },
    {
      "affs": [
        0
      ],
      "name": "Arti Soren"
    },
    {
      "affs": [
        3
      ],
      "name": "K. C. Muraleedharan",
      "orcid": "0000-0002-6762-7006"
    },
    {
      "affs": [
        3
      ],
      "name": "Subhash Kaushik",
      "orcid": "0000-0002-2851-1377"
    },
    {
      "affs": [
        2
      ],
      "name": "Shashikanth Jale",
      "orcid": "0000-0001-9986-5925"
    },
    {
      "affs": [
        0
      ],
      "name": "Bibaswan Biswas",
      "orcid": "0000-0003-3654-298X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e1dnpwx48xkcg.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31213909",
  "fulltext_url": null,
  "id": "e1dnpwx48xkcg",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/21/3909",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/e1dnpwx48xkcg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:42Z",
      "native_id": "10.3390/molecules31213909",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/21/3909"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:1420-3049",
      "subfield": "general"
    }
  ],
  "title": "Integrated Phytochemical, Antioxidant, and Chemometric Evaluation of Clinically Relevant Ocimum tenuiflorum Extracts from Diverse Geo-Climatic Regions",
  "title_text": "Integrated Phytochemical, Antioxidant, and Chemometric Evaluation of Clinically Relevant Ocimum tenuiflorum Extracts from Diverse Geo-Climatic Regions",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:20:49Z",
  "url": "https://research.draconitic.com/paper/e1dnpwx48xkcg",
  "venue": "Molecules",
  "versions": []
}