{
  "abstract": "Background The prognostic value of Cockcroft-Gault estimated creatinine clearance (CG-CrCl) in critically ill cerebrovascular disease (CVD) patients is unclear. Methods This retrospective cohort study included 8,732 adults from MIMIC-IV. CG-CrCl was examined continuously and by quartiles. Primary outcome was 30-day mortality; secondary outcomes were 90-day and 365-day mortality. Multivariable Cox models, restricted cubic splines, and two-piecewise linear regression assessed associations. Results Overall 30-day, 90-day, and 365-day mortality rates were 17.6%, 22.2%, and 28.8%, respectively. In fully adjusted models, each 1-standard deviation (SD; 45.46 mL/min) decrease in CG-CrCl was independently associated with increased mortality risk (30-day: HR 1.35, 95% CI 1.25–1.45; 90-day: HR 1.32, 95% CI 1.24–1.41; 365-day: HR 1.31, 95% CI 1.24–1.39). A significant nonlinear threshold effect was identified: the association became pronounced only below inflection points of 119.66, 114.84, and 114.89 mL/min for 30-, 90-, and 365-day mortality, respectively. Adding CG-CrCl did not significantly improve discrimination at any time point (all DeLong P > 0.05). Conclusion CG-CrCl is independently associated with short- and long-term mortality in critically ill CVD patients with a nonlinear threshold effect, suggesting it may serve as a readily available risk marker worthy of further validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department and Institution, Department of Emergency Medicine, The Affiliated Hospital of Qingdao University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hui Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e1enme50vzkgf.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-61894-9",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-61894-9",
  "id": "e1enme50vzkgf",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-61894-9",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2727|Acute Kidney Injury Research"
    ]
  ],
  "openalex": "W7169558465",
  "pdf_url": "https://www.nature.com/articles/s41598-026-61894-9_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/e1enme50vzkgf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:52Z",
      "native_id": "28e6c26d7e5448bd8954b3f836ab0876",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-61894-9"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Acute Kidney Injury Research",
      "subfield": "general"
    }
  ],
  "title": "Nonlinear association between cockcroft-gault creatinine clearance and all-cause mortality in critically ill cerebrovascular disease patients: a retrospective cohort study",
  "title_text": "Nonlinear association between cockcroft-gault creatinine clearance and all-cause mortality in critically ill cerebrovascular disease patients: a retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:52Z",
  "url": "https://research.draconitic.com/paper/e1enme50vzkgf",
  "venue": "Scientific Reports",
  "versions": []
}