{
  "abstract": "Regulatory T cells (Tregs) are essential for immune tolerance, with cAMP metabolism central to their suppressive function. Inducible cAMP early repressor (ICER) is a negative regulator of cAMP signalling. However, its role in Treg biology is not fully understood. Here we generated Foxp3-specific ICER knockout mice to assess ICER's function in Tregs. We found that ICER deficiency does not impair Treg development or suppression of effector T cell proliferation under homeostatic conditions. However, ICER-deficient Tregs display enhanced Foxp3 stability, increased glycolysis and proliferation but exhibit impaired suppression of IFN-γ production by effector T cells. In a dextran sodium sulphate-induced colitis model, loss of ICER in Tregs led to aggravated intestinal inflammation and tissue damage, without, however, a marked effect on gross disease parameters. These results identify ICER as a context-dependent modulator of Treg metabolism and inflammatory cytokine control, highlighting its potential role in regulating immune responses during inflammation.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.",
    "Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.",
    "Institute of Pathology, University Medical Center Mainz, Mainz, Germany.",
    "Translational Oncology at the University Medical Center Mainz (TRON), Mainz, Germany.",
    "Research Center for Immunotherapy (FZI), University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany.",
    "Institute of Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Aleksandra Lopez Krol"
    },
    {
      "affs": [
        0
      ],
      "name": "Luana Silva",
      "orcid": "0000-0001-7297-9586"
    },
    {
      "affs": [
        0
      ],
      "name": "Daniele C Nascimento"
    },
    {
      "affs": [
        0
      ],
      "name": "Sophie M Oberwalder"
    },
    {
      "affs": [
        0
      ],
      "name": "Hitikk Chawla"
    },
    {
      "affs": [
        1
      ],
      "name": "Gabriel Alberto Barbosa de Carvalho"
    },
    {
      "affs": [
        0
      ],
      "name": "Fatima Boukhallouk"
    },
    {
      "affs": [
        0
      ],
      "name": "Monica Romero"
    },
    {
      "affs": [
        2
      ],
      "name": "Anne Hausen"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Matthias M Gaida"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Luciana Berod"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "José Carlos Alves-Filho"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Tim Sparwasser"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e1nb11mfpkjwc.bib",
  "cited_by": 0,
  "doi": "10.1002/eji.70297",
  "fulltext_url": "https://europepmc.org/articles/PMC13669413",
  "id": "e1nb11mfpkjwc",
  "issns": [
    "0014-2980",
    "1521-4141"
  ],
  "landing_url": "https://europepmc.org/article/MED/42875971",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|T-cell and B-cell Immunology"
    ]
  ],
  "openalex": "W7222188704",
  "pdf_url": "https://europepmc.org/articles/PMC13669413?pdf=render",
  "pmcid": "PMC13669413",
  "pmid": "42875971",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e1nb11mfpkjwc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42875971",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42875971"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|T-cell and B-cell Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis.",
  "title_text": "Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/e1nb11mfpkjwc",
  "venue": "European journal of immunology",
  "versions": []
}