{
  "abstract": "We performed a systematic review to investigate the definition of mild to moderate active ulcerative colitis (UC), and to describe predictors of good response to treatment in clinical trials assessing 5-ASA and/or budesonide. Thirty-nine randomized controlled trials were included. The UC Disease Activity Index (UCDAI) was the most frequent score used for defining mild to moderate active UC (16 studies, 41%), followed by Clinical Activity Index in 11 studies (28.2%). Four different cut-offs were used to define mild to moderate active UC using the UCDAI. The most frequently reported predictors of good response to treatment was a mild and moderate disease activity. There is heterogeneity in the definition of mild to moderate active UC in randomized clinical trials. A standardized definition of mild to moderate active UC used for inclusion of patients in clinical trials is needed.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Bénédicte Caron"
    },
    {
      "name": "Vipul Jairath"
    },
    {
      "name": "Ferdinando D’amico"
    },
    {
      "name": "Kristine Paridaens"
    },
    {
      "name": "Fernando Magro"
    },
    {
      "name": "Silvio Danese"
    },
    {
      "name": "Laurent Peyrin-Biroulet"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e1qzaytyd4jy4.bib",
  "cited_by": 18,
  "doi": "10.1002/ueg2.12283",
  "fulltext_url": null,
  "id": "e1qzaytyd4jy4",
  "issns": [
    "2050-6406",
    "2050-6414"
  ],
  "landing_url": "https://hal.univ-lorraine.fr/hal-04167999v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W4293368040",
  "pdf_url": "https://hal.univ-lorraine.fr/hal-04167999/document",
  "pmcid": null,
  "pmid": "36029157",
  "published": "2026-09-17",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/e1qzaytyd4jy4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "hal-04167999",
      "source": "hal",
      "url": "https://hal.univ-lorraine.fr/hal-04167999v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Inflammatory Bowel Disease",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Definition of mild to moderate ulcerative colitis in clinical trials: A systematic literature review",
  "title_text": "Definition of mild to moderate ulcerative colitis in clinical trials: A systematic literature review",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:36Z",
  "url": "https://research.draconitic.com/paper/e1qzaytyd4jy4",
  "venue": "United European Gastroenterology Journal",
  "versions": []
}