{
  "abstract": "Background: The objective of this study was to describe the clinical features, treatment and prognosis of immunocompetent children with human herpes virus 7 (HHV-7)-associated encephalitis.\n\nMethods: Sixteen children with HHV-7-associated encephalitis were diagnosed by metagenomic next-generation sequencing of their cerebrospinal fluid and followed up for 3 months.\n\nResults: The median age of the cohort was 8.6 years (range, 1.4–11.8) and comprised of 8 males and 8 females. The most common presenting symptoms were fever (12/16, 75.0%), headache (10/16, 62.5%), and vomiting (8/16, 50.0%). Abnormal electroencephalography and encephalitis-related neuroimaging findings were obtained in 50.0% (6/12) and 25.0% (4/16) of the patients, respectively. 68.8% of the patients were treated with either acyclovir or ganciclovir. Unfavorable outcomes occurred in three patients, including the death of a 2-year-old child.\n\nConclusion: Pediatric HHV-7-associated encephalitis generally has a favorable prognosis, but severe cases do occur. Early recognition is important for increasing clinicians’ awareness of this condition.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatric Neurology, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Clinical Research Center for Pediatric Diseases"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Dongling Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinqiu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuelin Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuyi Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Qingqing Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Fengping Wei"
    },
    {
      "affs": [
        0
      ],
      "name": "Yiyan Ruan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e20e2mfq8tytp.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1959563",
  "fulltext_url": null,
  "id": "e20e2mfq8tytp",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1959563/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/e20e2mfq8tytp.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:21:27Z",
      "native_id": "10.3389/fneur.2026.1959563",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1959563/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-2295",
      "subfield": "neurology"
    }
  ],
  "title": "Human herpesvirus 7-associated encephalitis diagnosed by metagenomic next-generation sequencing in pediatric patients: a retrospective study",
  "title_text": "Human herpesvirus 7-associated encephalitis diagnosed by metagenomic next-generation sequencing in pediatric patients: a retrospective study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:26Z",
  "url": "https://research.draconitic.com/paper/e20e2mfq8tytp",
  "venue": "Frontiers in Neurology",
  "versions": []
}