{
  "abstract": "Climate change is increasingly recognized as a determinant of metabolic health. Emerging evidence indicates that rising temperatures impair glucose homeostasis-specifically through reduced brown adipose tissue activity and increased insulin resistance-thereby exacerbating type 2 diabetes mellitus (T2DM) risk. Concurrently, food systems drive substantial greenhouse gas emissions (GHGE), with gender-differentiated dietary patterns uniquely influencing both environmental impact and health outcomes. In this perspective, we move beyond well-established separate links to propose an original integrated and systemic conceptual framework. This framework connects gender-related drivers in dietary behaviors, GHGE, global warming, brown adipose tissue dysfunction, and T2DM risk into an integrated multidimensional feedback model, providing a novel basis to generate hypotheses for future mechanistic, epidemiological, and intervention studies, supporting gender-sensitive prevention strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Gender-Specific Prevention and Health Unit Centre For Gender-Specific Medicine Istituto Superiore di Sanità Rome Italy."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Massimo D'Archivio"
    },
    {
      "affs": [
        0
      ],
      "name": "Giulia Zanchi"
    },
    {
      "affs": [
        0
      ],
      "name": "Alessia Tammaro"
    },
    {
      "affs": [
        0
      ],
      "name": "Roberta Masella"
    },
    {
      "affs": [
        0
      ],
      "name": "Claudia Cataldo",
      "orcid": "0000-0002-2306-7043"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e21b32gkydg1j.bib",
  "cited_by": 0,
  "doi": "10.1002/gch2.70140",
  "fulltext_url": "https://europepmc.org/articles/PMC13678276",
  "id": "e21b32gkydg1j",
  "issns": [
    "2056-6646"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898555",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2307|Climate Change and Health Impacts"
    ]
  ],
  "openalex": "W7222930226",
  "pdf_url": "https://europepmc.org/articles/PMC13678276?pdf=render",
  "pmcid": "PMC13678276",
  "pmid": "42898555",
  "published": "2026-10-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e21b32gkydg1j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:33Z",
      "native_id": "MED:42898555",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898555"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Climate Change and Health Impacts",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Global Warming and Type 2 Diabetes: Sex and Gender as Drivers in a Multidimensional Feedback Loop.",
  "title_text": "Global Warming and Type 2 Diabetes: Sex and Gender as Drivers in a Multidimensional Feedback Loop.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:33Z",
  "url": "https://research.draconitic.com/paper/e21b32gkydg1j",
  "venue": "Global challenges (Hoboken, NJ)",
  "versions": []
}